Geminin (E5Q9S) XP ® Rabbit mAb 52508S from Cell Signaling Technology

Product Specs
ItemGeminin (E5Q9S) XP ® Rabbit mAb
CompanyCell Signaling Technology
Price $402.00 Inquire
Catalog Number52508S
Quantity100 µl
ApplicationsW, IP, IHC-P, IF-IC
ReactivityH, Mk
TargetGMNN
IsotypeIgG
HostRabbit
NCBI Full Gene Namegeminin DNA replication inhibitor
NCBI Gene AliasesGem, MGORS6
ClonalityMonoclonal
Research AreaCell Cycle / Checkpoint Control
Molecular Weight25

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Cell Signaling Technology

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Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Evaluating carboplatin and PARP inhibitor combination efficacy using high-grade serous carcinoma spheroids and organoidsCancer Biology & TherapyDecember 31, 2026Emily J. Tomas, Jennifer Davis, Yudith Ramos Valdes, Trevor G. Shepherd139 clone JBW301 (05-636, 1:500) was purchased from MilliporeSigma (Oakville, ON, Canada). Geminin (52508, 1:800) was purchased from Cell Signaling Technology (Whitby, ON, Canada). The fluorophore-conjugated

(2) GALNT3 is a novel target driving lymphomagenesis via O-glycosylation of FGFR2Cell Communication and SignalingDecember 17, 2025Ruixin Sun, Wenhan Wang, Yixuan Gao, Kasimujiang Aximujiang, Yan Li, Agida Innocent, Zizhen Xu, Jiao Macyclin A2 (Cat No. 91500T), cyclin E1 (Cat No. 20808T), cyclin D1 (Cat No. 2978T), Geminin (Cat No. 52508T), p-ERK (Cat No. 4370T), t-ERK (Cat No.4692T), p-AKT (Cat No.4060T), t-AKT (Cat No.4691 S), p-STAT5

(3) Unveiling and stratifying cell cycle-dependent drug efficacy using a single-cell PLOM-CON approach with correlation anomaly and presage protein signalsCommun BiolOctober 30, 2025Yoshiyuki Noguchi, Rina Kunishige, Naeko Shinozaki-Narikawa, Hiroshi Yamashita, Kazuyuki Aihara, Masayuki Murata, Fumi Kanop-Cdc2(Thr161) (Applied Biological Materials; Y011134; Clone 0907; 1:50), Geminin (Cell Signaling Technology; 52508; Clone 1; 1:800). The secondary antibodies used were: anti-Rabbit IgG, Alexa Fluor 555 (abcam; ab150074;

(4) DNA methylation influences human centromere positioning and functionNature GeneticsSeptember 4, 2025Catalina Salinas-Luypaert, Danilo Dubocanin, Rosa Jooyoung Lee, Lorena Andrade Ruiz, Riccardo Gamba, Marine Grison, Leonid Velikovsky, Annapaola Angrisani, Andrea Scelfo, Yuan Xu, et al.Antibodies Incorporated, 15-235-0001), rabbit anti-Geminin (1:500; clone E5Q9S; Cell Signaling Technology, 52508), rabbit monoclonal anti-CDT1 (1:500; clone EPR17891; Abcam, ab202067), rabbit anti-H3K9me3 (1 μg ml−1;

(5) Orientia tsutsugamushi modulates p53, the cell cycle, and genotoxicity to maintain its intracellular nicheNat CommunAugust 19, 2025Paige E. Allen, David L. Armistead, Svetlana Blinova, Jason A. Carlyon[#8052]; 1:1000), rabbit anti-GFP (Invitrogen [A11122]; 1:1000), rabbit anti-GMNN (Cell Signaling [#52508]; 1:1000), rabbit anti-cdc25a (Cell Signaling [#3652]; 1:1000), rabbit anti-phosphorylated-Histone H2A.X

(6) Cytosolic Phospholipase A2 Determines Intercellular Heterogeneity of Stress Granules and Chemotherapy ResponseCancer DiscoveryJuly 3, 2025Alexandra Redding, Guillaume Fonteneau, Stefan Heinrich, Matthias M. Gaida, Elda GrabockaGeminin (1:50, Cell Signaling Technology; cat. no.79148; 1:100, Cell Signaling Technology; cat. no.52508S), CDT1 (1:50, Cell Signaling Technology; cat. no.3386, RRID: AB_2076879), Cytokeratin 8 (1:100, DSHB;

(7) Oxidative Phosphorylation Is a Metabolic Vulnerability of Endocrine Therapy–Tolerant Persister Cells in ER+ Breast CancerCancer ResearchMarch 14, 2025Steven Tau, Mary D. Chamberlin, Huijuan Yang, Jonathan D. Marotti, Patricia C. Muskus, Alyssa M. Roberts, Melissa M. Carmichael, Lauren Cressey, Christo Philip C. Dragnev, Eugene Demidenko, et al.Medical, CRM325B), cleaved caspase 3 (Cell Signaling Technology 9505), geminin (Cell Signaling Technology 52508), ERα (Dako SP1), MT-CO2 (Sigma Aldrich HPA051505), OXPHOS antibody cocktail (Abcam ab110411), c-Myc

(8) Spatiotemporal analysis of ratiometric biosensors in live multicellular spheroids using SPoRTSCell Reports MethodsFebruary 24, 2025Matthew J. Borrelli, Bart Kolendowski, Gabriel E. DiMattia, Trevor G. ShepherdMilliporeSigma, T5168, RRID: AB_477579) plus either anti-Geminin (1:800; Cell Signaling Technology, 52508, RRID: AB_3096494), anti-phospho-histone H3 (Ser10) (1:200; Cell Signaling Technology, 9701, RRID: AB_331535),

(9) Toxoplasma gondii infection induces early host cell cycle arrest and DNA damage in primary human host cells by a MYR1-dependent mechanismCommunications BiologyDecember 16, 2024Zahady D. Velásquez, Lisbeth Rojas-Baron, Iván Conejeros, Carlos Hermosilla, Anja Taubert(pS139),Cell Signalling,80312S,Mouse,1:400 PCNA,Abcam,ab18197,Rabbit,1:200 Geminin,Cell Signalling,52508,Rabbit,1:800 Toxoplasma gondii,Thermo Fisher,PA1-7256,Goat,1:100 β-catenin,Abcam,ab32572,Rabbit,1:200 Primary

(10) Sustained ERK signaling promotes G2 cell cycle exit and primes cells for whole-genome duplicationDevelopmental cellJuly 8, 2024Guerrero Zuniga A, Aikin TJ, McKenney C, Lendner Y, Phung A, Hook PW, Meltzer A, Timp W, Regot S.RESOURCE,SOURCE,IDENTIFIER Antibodies,Antibodies,Antibodies Rabbit anti-Geminin,Cell Signaling Technology,Cat# 52508 Rabbi anti-pH2A.X,Cell Signaling Technology,Cat# 9718 Rabbit anti-p53,Cell Signaling Technology,Cat#

(11) Suppressing SENP1 inhibits esophageal squamous carcinoma cell growth via SIRT6 SUMOylationCell Oncol (Dordr)July 2, 2024Jianmin Gu, Shaoyuan Zhang, Dong Lin, Wenhan Wang, Jinke Cheng, Quan Zheng, Hao Wang, Lijie TanA19693), Bax (CST, #2772), Caspase-3 (CST, #9661), Thymidine Kinase 1 (CST, #28755), Geminin (CST, #52508), Phospho-CDK1 (Thr161) (CST, #9114), Cyclin A2 (CST, #91500), SIRT6 (Abcam, ab191385), SUMO1 (CST,

(12) CDK4/6 activity is required during G 2 arrest to prevent stress-induced endoreplicationScienceMay 3, 2024Connor McKenney, Yovel Lendner, Adler Guerrero Zuniga, Niladri Sinha, Benjamin Veresko, Timothy J. Aikin, Sergi RegotPBS wash. Gamma H2A.X (CST, 9718, RRID: AB_2118009) primary antibody was used at 1:500. Geminin (CST, 52508), Cyclin A2 (CST, 67955), and phospho-Rb (CST, 8516, RRID: AB_11178658) primary antibodies were used

(13) scAbsolute: measuring single-cell ploidy and replication statusGenome BiolMarch 4, 2024Michael P. Schneider, Amy E. Cullen, Justina Pangonyte, Jason Skelton, Harvey Major, Elke Van Oudenhove, Maria J. Garcia, Blas Chaves Urbano, Anna M. Piskorz, James D. Brenton, et al.were incubated overnight at 4 ∘C, 300RPM in Primary Antibody Solution (Geminin E5Q9S XP Rabbit mAb (#52508, Cell Signalling Technologies)) diluted 1:100 in PBS plus 10% Normal Goat Serum) at a ratio of 100 µL

(14) Therapeutic targeting of metabolic vulnerabilities in cancers with MLL3/4-COMPASS epigenetic regulator mutationsThe Journal of clinical investigationJuly 3, 2023Zhao Z, Cao K, Watanabe J, Philips CN, Zeidner JM, Ishi Y, Wang Q, Gold SR, Junkins K, Bartom ET, et al.ASH2L (CST, 5019), H3 Ser10-p (CST 53348), CDT1 (CST, 8064), Cyclin B1 (CST, 12231), Geminin (CST, 52508), Cyclin E1 (CST, 20808), Cyclin A2 (CST, 91500), p-cdc2 (CST, 4539), PARP (CST, 9542) Caspase3 (CST,

(15) Reciprocal inhibition of PIN1 and APC/C(CDH1) controls timely G1/S transition and creates therapeutic vulnerabilityResearch squareJanuary 19, 2023Ke S, Dang F, Wang L, Chen JY, Naik MT, Thavamani A, Liu Y, Li W, Kim N, Naik NM, et al.mAb (4513), anti-Phospho-MAPK/CDK Substrates (PXS*P or S*PXR/K) (2325) and anti-Geminin rabbit mAb (52508) antibodies were purchased from Cell Signaling Technology. Anti-Emi1 mouse mAb (376600) was purchased

(16) BRCA1-methylated triple negative breast cancers previously exposed to neoadjuvant chemotherapy form RAD51 foci and respond poorly to olaparibFrontiers in oncologyJanuary 1, 2023Velazquez C, Orhan E, Tabet I, Fenou L, Orsetti B, Adélaïde J, Guille A, Thézénas S, Crapez E, Colombo PE, et al.anti-RAD51 PC130 1:300 (Merck Millipore Sigma Aldrich, Saint Quentin Fallavier, France), rabbit anti-geminin 52508 1:200 (CST OZYME, Saint Cyr l’Ecole, France), mouse anti-BRCA1 sc-6954 1:100 (SCBT, Heidelberg, Germany),

(17) Intracellular Crowding by Bio‐Orthogonal Hydrogel Formation Induces Reversible Molecular StasisAdvanced MaterialsAugust 1, 2022Laura J. Macdougall, Timothy E. Hoffman, Bruce E. Kirkpatrick, Benjamin D. Fairbanks, Christopher N. Bowman, Sabrina L. Spencer, Kristi S. Ansethovernight at 4 °C in the presence of 3% BSA. Primary antibodies used in this study were: Geminin (1:500, #52508, Cell Signaling Technology), Phospho-Rb (1:1000, (Ser807/811), #8516, Cell Signaling Technology), Recombinant

(18) Cyclin B/CDK1 and Cyclin A/CDK2 phosphorylate DENR to promote mitotic protein translation and faithful cell divisionNature communicationsFebruary 3, 2022Clemm von Hohenberg K, Müller S, Schleich S, Meister M, Bohlen J, Hofmann TG, Teleman AA.Sigma #F3165), GAPDH (1:2000, rabbit, Cell Signallling #2118), Geminin (1:1000, rabbit, Cell Signaling #52508), pHH3 (Serine 10) (for WB: 1:500, rabbit, Cell Signaling #9701; for flow cytometry: 1:100, mouse, Cell Signaling

(19) A viral histone-like protein exploits antagonism between linker histones and HMGB proteins to obstruct the cell cycleCurrent biology : CBDecember 6, 2021Lynch KL, Dillon MR, Bat-Erdene M, Lewis HC, Kaai RJ, Arnold EA, Avgousti DC.Gerace,N/A Mouse Anti-VII,Laboratory of H. Wodrich33,N/A Rabbit Anti-Geminin,Cell Signaling Technology,Cat: 52508 Rabbit Anti-CDT1,Cell Signaling Technology,Cat: 8064S Rabbit Anti-Thymidine Kinase 1,Cell Signaling Technology

(20) Sinomenine Inhibits the Growth of Ovarian Cancer Cells Through the Suppression of Mitosis by Down-Regulating the Expression and the Activity of CDK1OncoTargets and therapyJanuary 1, 2021Qu X, Yu B, Zhu M, Li X, Ma L, Liu C, Zhang Y, Cheng Z.Western blots were performed as described previously.29 The primary antibodies were listed as follows: Geminin (52508), CDT1 (8064), Thymidine Kinase 1 (28755), P-Histone H3 (53348), Cyclin A2 (91500), Cyclin B1 (12231),

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Geminin (E5Q9S) XP ® Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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Geminin (E5Q9S) XP ® Rabbit mAb from Cell Signaling Technology

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