Fig 2: BCL6 expression in endometrium collected during laparoscopy: (A) Representative images of BCL6 expression in the endometrium of patients without endometriosis (controls), patients with stage I or stage IV endometriosis with or without associated fertility ( 50 µm); (B) BCL6 HSCOREs in control patients (n = 11) and (B) patients with stage I (n = 6) or stage IV, fertile (n = 5) or infertile (n = 5); (C) mean normalized BCL6 intensity distributions measured on all scanned sections in each group of patients. * p = 0.05, and ** p = 0.01.

Fig 3: BCL6 expression in the endometrium of infertile patients with and without endometriosis: (A) representative images of BCL6 expression ( 50 µm); (B) HSCOREs in the endometrium of infertile women without endometriosis (controls, n = 29 and infertile patients with endometriosis (n = 17); (C) mean normalized BCL6 intensity distributions measured on all scanned sections in each group of patients. * p = 0.05, ** p = 0.01, and *** p = 0.001.

Fig 4: Image processing workflow to quantify epithelial endometrial BCL6 expression: (A) original image of one isolated region from the whole scanned image registered in RGB space, (B) grey level green component of the RGB image (C) automatic thresholding to extract all BCL6 expression (green labeling in stromal and epithelial compartments), (D) resulting binary image after filtering stromal cells, (D) visualization of the resulting image in 256 gray levels) after background elimination by multiplying the binary image with the grey level green component, (E) resulting intensity distribution, (F) Histogram of intensities.