IL-17RC Antibody AF2270 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemIL-17RC Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $499.00Supplier Page View Company Product Page
Catalog NumberAF2270
IsotypeIgG
HostGoat
Quantity100 ug (also 25 ug)
Conjugate/TagUnconjugated
ReactivityMouse,Transgenic Mouse
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
TargetIL-17RC
ApplicationsWB, FCM, FA, MC, Neut
ClonalityPolyclonal
ImmunogenMouse myeloma cell line NS0-derived recombinant mouse IL-17 RC, Leu21-Trp465, Accession # AAH04759
ConcentrationLYOPH
PurityAntigen Affinity-purified
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution
NCBI Full Gene Nameinterleukin 17 receptor C
NCBI Gene AliasesCANDF9, IL17-RL, IL17RL

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Specificity: Detects mouse IL-17 RC in direct ELISAs and Western blots. In direct ELISAs, approximately 10% cross-reactivity with recombinant human IL-17 RC is observed and less than 5% cross-reactivity with recombinant mouse (rm) IL-17 RD and rmIL-17B R is observed.

Sizes Available: 100 ug (also 25 ug)

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) CMTM6 suppresses cell-surface expression of death receptor FAS in mice but not in humansEMBO ReportsFebruary 3, 2026Tereza Semberova, Michaela Pribikova, Veronika Cimermanova, Tijana Trivic, Rafik Haderbache, Darina Paprckova, Luca Christen, Helena Kissiova, Ondrej Stepanek, Peter DraberBioLegend and FoxP3 PE-Cy7 (#25-5773-80) from Thermo Fisher Scientific. Unconjugated Anti-IL-17RC (#AF2270) from R&D Systems was detected with donkey anti-goat IgG (H + L) AF647 (#705-605-147) from Jackson Immunoresearch. For

(2) STAT1 Employs Myeloid Cell–Extrinsic Mechanisms to Regulate the Neutrophil Response and Provide Protection against Invasive Klebsiella pneumoniae Lung InfectionImmunoHorizonsJanuary 1, 2024Shekina Gonzalez-Ferrer, Hernán F. Peñaloza, Rick van der Geest, Zeyu Xiong, Atish Gheware, Mohammadreza Tabary, Megan Kochin, Kathryn Dalton, Henry Zou, Dequan Lou, et al.Cell) at 48 h before infection or 50 μg/mouse of IL-17RC neutralizing Ab (Mouse IL17-RC Ab, catalog no. AF2270, R&D Systems) 6 h after infection with the respective IgG control Abs (clone LTF-2, Bio X Cell; and

(3) CMTM4 is a subunit of the IL-17 receptor and mediates autoimmune pathologyNature immunologyNovember 1, 2022Knizkova D, Pribikova M, Draberova H, Semberova T, Trivic T, Synackova A, Ujevic A, Stefanovic J, Drobek A, Huranova M, et al.(sc-398161) and p38 (sc-728) were from Santa Cruz Biotechnology; murine IL-17RA (MAB4481), IL-17RC (AF2270), IL-17RD (AF2276) and TNFR1 (AF-425-PB) were from R&D Systems; and TRAF6 (ab40675) was from Abcam.

(4) Minocycline reverses IL-17A/TRAF3IP2-mediated p38 MAPK/NF-κB/iNOS/NO-dependent cardiomyocyte contractile depression and deathCellular signallingSeptember 1, 2020Yoshida T, Das NA, Carpenter AJ, Izadpanah R, Kumar SA, Gautam S, Bender SB, Siebenlist U, Chandrasekar B.

(5) Pulmonary Regnase-1 orchestrates the interplay of epithelium and adaptive immune systems to protect against pneumoniaMucosal immunologyJuly 1, 2018Nakatsuka Y, Vandenbon A, Mino T, Yoshinaga M, Uehata T, Cui X, Sato A, Tsujimura T, Suzuki Y, Sato A, et al.was administered. For the neutralization of IL-17RC, 100 μg of anti-IL-17RC Ab (Novus Biologicals, AF2270) was suspended by PBS and administered simultaneously with heat-killed P. aeruginosa. Immunoblot Cell

(6) Respiratory syncytial virus infection of newborn CX3CR1-deficient mice induces a pathogenic pulmonary innate immune responseJCI insightSeptember 7, 2017Das S, Raundhal M, Chen J, Oriss TB, Huff R, Williams JV, Ray A, Ray P.4 or 7 p.i. Infected pups were treated with 50 μg goat anti-mIL-17RC antibody (R&D Systems, catalog AF2270) or goat IgG isotype control (R&D Systems, catalog AB-108-C) by the intraperitoneal route on days 2

(7) Th17 cells mediate clade-specific, serotype-independent mucosal immunityImmunityDecember 23, 2011Chen K, McAleer JP, Lin Y, Paterson DL, Zheng M, Alcorn JF, Weaver CT, Kolls JK.

(8) TLR2 deficiency leads to increased Th17 infiltrates in experimental brain abscessesJournal of immunology (Baltimore, Md. : 1950)June 1, 2009Nichols JR, Aldrich AL, Mariani MM, Vidlak D, Esen N, Kielian T.

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IL-17RC Antibody

IL-17RC Antibody

IL-17RC Antibody

IL-17RC Antibody

IL-17RC Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (8)

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IL-17RC Antibody from R&D Systems, a Bio-Techne Brand

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