MyBioSource.com's Rabbit anti c-Met Polyclonal Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, Immunohistochemistry, Immunoprecipitation, and Western Blot.
Description
The c-Met oncogene, a member of the tyrosine kinase superfamily, was originally isolated from chemical carcinogen-treated human osteogenic sarcoma cell line by transfection analysis in NIH/3T3 cells. The Met proto-oncogene product was identified as a trans-membrane receptor-like protein with tyrosine kinase activity that is expressed in many tissues. The mature c-Met protein is a disulfide-linked heterodimer with Mw 190 kDa composed of a heavily glycosylated domain, a single transmembrane domain and a cytoplasmic tyrosine kinase domain. The c-Met gene product has been identified as the cell surface receptor for hepatocyte growth factor, a plasminogen-like protein thought to be a humoral mediator of liver regeneration