Rb1 (Tumor Suppressor Protein) Antibody MBS4380201 from MyBioSource.com

Product Specs
ItemRb1 (Tumor Suppressor Protein) Antibody
CompanyMyBioSource.com
Price $190.00Supplier Page View Company Product Page
Catalog NumberMBS4380201
Quantity0.02 mg (With BSA & Azide at 0.2mg/ml)
ClonalityMonoclonal
ReactivityHuman, Mouse. Others not known
Format200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml
ApplicationsImmunohistochemistry (IHC) Formalin
SpeciesRabbit
Molecular Weight105kDa
TargetRb1
NCBI Full Gene NameRB transcriptional corepressor 1
NCBI Gene AliasespRb, PPP1R130, pp110, RB, p105-Rb, OSRC
Conjugate/TagUnconjugated
IsotypeIgG
CloneRB1/2313R

Specifications/Features

Recognizes a 105kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. Its epitope is localized between aa 703-772. It shows no cross reaction with p107 or p130. It specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells. It does not stain the Rb-negative BT549 cells. It reacts with the hyperphosphorylated as well as the un (under) phosphorylated form of the Rb protein. Retinoblastoma gene product plays a key role in cell cycle control. It has been identified as a tumor suppressor gene whose loss of its function leads to tumor development. It is widely expressed in a variety of human tissues including breast, esophageal, squamous cell and cervical carcinoma

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