The CSK Mouse mAb Antibody from MyBioSource.com is a Mouse Monoclonal antibody. This antibody recognizes Human, Mouse, Rat, and Non-Human Primate antigen. The CSK Mouse mAb Antibody has been shown to work in the following applications: ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry, and Western Blot.
Description
Carboxy-terminal Src kinase (Csk) is a ubiquitously expressed nonreceptor tyrosine kinase that negatively regulates the Src family kinases (SFK) by phosphorylation of the SFK carboxy-terminal tyrosine. Phosphorylated carboxy-terminal tyrosine binds to the SH2 domain of SFK intramolecularly and leads to folding and inactivation of the SFK. This Csk-catalyzed SFK tyrosine phosphorylation is highly specific and exclusive. The SFK carboxy-terminal tyrosine is the only known physiological substrate of Csk. Tissue specificity: Expressed in lung and macrophages