The PIAS3 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Mouse, Rat, Bovine, Canine, and Porcine antigen. The PIAS3 Antibody has been shown to work in the following applications: Immunohistochemistry, and Western Blot.
Description
PIAS3 is found to interact specifically with phosphorylated STAT3 in Interleukin -6 (IL-6) activated murine myeloblast M1 cells. This interaction is mediated via PIAS3 binding to the STAT3 DNA binding domain. Hence, STAT3 transcriptional activity is inhibited by the physical prevention of its binding to target genes