Mouse Anti-Complement 3d Antibody MBS4381315 from MyBioSource.com

Product Specs
ItemMouse Anti-Complement 3d Antibody
CompanyMyBioSource.com
Price $190.00Supplier Page View Company Product Page
Catalog NumberMBS4381315
Quantity0.02 mg (With BSA & Azide at 0.2mg/ml)
ApplicationsELISA (EIA)
ReactivityHuman
Format200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml
PurityPurified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Conjugate/TagUnconjugated
SpeciesMouse
Molecular Weight35kDa (predicted)
TargetComplement 3d (C3d)
IsotypeIgG2b kappa
CloneC3D/2891
ClonalityMonoclonal
NCBI Full Gene Namecomplement C3
NCBI Gene AliasesCPAMD1, HEL-S-62p, ASP, ARMD9, C3a, C3b, AHUS5

Specifications/Features

The complement component proteins, C2, C3, C4 and C5, are potent anaphylatoxins that are released during complement activation. Binding of these proteins to their respective G protein-coupled receptors, C3aR, C1R and C5aR, induces proinflammatory events, such as cellular degranulation, smooth muscle contraction, arachidonic acid metabolism, cytokine release, leukocyte activation and cellular chemotaxis. C3d is a terminal degradation product of C3 that plays an important role in modulation of the adaptive immune response through the interaction with complement receptor type 2 (CR2). CR2 is important in the switched-isotype, high-affinity and memory humoral immune responses to T-dependent foreign antigens, as well as in the development of the natural antibody repertoire. This pH- and ionic strength-dependent association of C3d with CR2 represents a link between innate and adaptive immunity

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