The Phospho-CRKII (Tyr221) Rabbit pAb Antibody from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Human antigen. The Phospho-CRKII (Tyr221) Rabbit pAb Antibody has been shown to work in the following applications: Immunocytochemistry, Immunofluorescence, and Western Blot.
Description
The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling