Rabbit Anti-Thymidine Phosphorylase/PD-ECGF Antibody MBS4380543 from MyBioSource.com

Product Specs
ItemRabbit Anti-Thymidine Phosphorylase/PD-ECGF Antibody
CompanyMyBioSource.com
Price $190.00Supplier Page View Company Product Page
Catalog NumberMBS4380543
Quantity0.02 mg (With BSA & Azide at 0.2mg/ml)
ClonalityMonoclonal
ReactivityHuman, Mouse, Rat. Others not known
Format200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml
ApplicationsImmunohistology (Formalin-Fixed)
SpeciesRabbit
Molecular Weight55kDa
TargetThymidine Phosphorylase/PD-ECGF
NCBI Full Gene Namethymidine phosphorylase
IsotypeIgG
CloneTYMP/2890R
Conjugate/TagUnconjugated
NCBI Gene AliasesMEDPS1, MTDPS1, ECGF, TP, MNGIE, ECGF1, hPD-ECGF, PDECGF
PurityPurified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Specifications/Features

Recognizes a protein (amino acid 482) of 55kDa (in vivo 110kDa homodimer), identified as platelet-derived endothelial growth factor (PD-ECGF), same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate, it catalyzes the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. Its enzymatic activity is crucial for angiogenic activity (metabolite is angiogenic). Higher levels of serum TP/PD-ECGF are observed in cancer patients. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites (e.g. 5'-deoxy-5-fluorouridine to 5-FU). High intra-cellular levels of TP/PD-ECGF are associated with increased chemosensitivity to such antimetabolites

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