Rabbit Anti-TNFS15/VEGI Antibody MBS4380378 from MyBioSource.com

Product Specs
ItemRabbit Anti-TNFS15/VEGI Antibody
CompanyMyBioSource.com
Price $190.00Supplier Page View Company Product Page
Catalog NumberMBS4380378
Quantity0.02 mg (With BSA & Azide at 0.2mg/ml)
ReactivityHuman. Others not known
Format200ug/ml of Ab purified by Protein A Column. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml
SpeciesRabbit
Molecular Weight22kDa
TargetTNFS15/VEGI (Vascular Endothelial Growth Inhibitor)
NCBI Gene AliasesTL1, VEGI, TNLG1B, TL1A, VEGI192A
Conjugate/TagUnconjugated
ApplicationsImmunohistochemistry-paraffin (IHC-p)
IsotypeIgG
CloneVEGI/2052R
NCBI Full Gene NameTNF superfamily member 15
ClonalityMonoclonal

Specifications/Features

VEGI is an anti-angiogenic cytokine that belongs to tumor necrosis factor superfamily, member 15 (TNFSF15). This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Reduced expression of VEGI has been reported as a marker of poor prognosis in breast cancer

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