Rabbit Anti-CD1a/HTA1 Antibody MBS4381376 from MyBioSource.com

Product Specs
ItemRabbit Anti-CD1a/HTA1 Antibody
CompanyMyBioSource.com
Price $190.00Supplier Page View Company Product Page
Catalog NumberMBS4381376
Quantity0.02 mg (With BSA & Azide at 0.2mg/ml)
Format200ug/ml of Ab Purified by Protein A Column. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml
ApplicationsImmunohistochemistry (IHC) Paraffin
SpeciesRabbit
TargetCD1a/HTA1
NCBI Gene AliasesR4, FCB6, HTA1, T6, CD1
Conjugate/TagUnconjugated
ReactivityHuman (Hu)
IsotypeIgG
NCBI Full Gene NameCD1a molecule
PurityPurified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Molecular Weight49kDa
ClonalityPolyclonal

Specifications/Features

At least five CD1 genes (CD1a, b, c, d, and e) are identified. CD1 proteins have been demonstrated to restrict T cell response to non-peptide lipid and glycolipid antigens and play a role in non-classical antigen presentation. CD1a is a non-polymorphic MHC Class 1 related cell surface glycoprotein, expressed in association with Beta-2 microglobulin. Anti-CD1a labels Langerhans cell histiocytosis (Histiocytosis X), extranodal histiocytic sarcoma, a subset of T-lymphoblastic lymphoma/leukemia, and interdigitating dendritic cell sarcoma of the lymph node. When combined with antibodies against TTF-1 and CD5, anti-CD1a is useful in distinguishing between pulmonary and thymic neoplasms since CD1a is consistently expressed in thymic lymphocytes in both typical and atypical thymomas, but only focally in 1/6 of thymic carcinomas and not in lymphocytes in pulmonary neoplasms. Anti-CD1a is reported to be a new marker for perivascular epithelial cell tumor (PEComa)

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