MerTK (Innate Immune Checkpoint) Antibody MBS4380783 from MyBioSource.com

Product Specs
ItemMerTK (Innate Immune Checkpoint) Antibody
CompanyMyBioSource.com
Price $190.00Supplier Page View Company Product Page
Catalog NumberMBS4380783
SpeciesMouse
PurityPurified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
ReactivityHuman (Hu)
ApplicationsImmunohistochemistry-paraffin (IHC-p)
CloneMERTK/3015
IsotypeIgG
Conjugate/TagUnconjugated
NCBI Gene Aliasesc-Eyk, MER, Tyro12, c-mer, RP38
NCBI Full Gene NameMER proto-oncogene, tyrosine kinase
TargetMerTK
Molecular Weight110kDa
Format200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml
ClonalityMonoclonal
Quantity0.02 mg (With BSA & Azide at 0.2mg/ml)

Specifications/Features

MerTK, also called c-Mer, is a member of the Mer/Axl/Tyro3 receptor kinase family. It is a 984 residue transmembrane protein made up of one tyrosine kinase domain, two Fibronectin type-III domains and two immunoglobulinlike C2-type domains. MerTK is the mammalian ortholog of the chicken retroviral oncogene product v-Eyk. This protein plays a critical role in macrophage activation, platelet aggregation, clot stability and the efficient removal of apoptotic cells. Specifically, MerTK acts as a signaling molecule, triggering outer segment ingestion in the retinal pigment epithelium (RPE) phagocytic process. Evidence suggests that MerTK signals via interaction with phosphatidylinositol-specific phospholipase C 2). When the gene encoding for MerTK is mutated, the RPE phagocytosis pathway is disrupted and autosomal recessive retinitis pigmentosa (RP) may result, leading to degeneration of retinal photoreceptor cells

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