The FZD10 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Human, Mouse, and Non-Human Primate antigen. The FZD10 Antibody has been shown to work in the following applications: ELISA, Immunocytochemistry, Immunofluorescence, and Western Blot.
Description
Function: Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).
Subunit Structure: Interacts with WNT7B (By similarity). Interacts with MYOC (PubMed:19188438).
Post-translational Modifications: Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.
Similarity: Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.The FZ domain is involved in binding with Wnt ligands. Belongs to the G-protein coupled receptor Fz/Smo family