The Anti-DR5 Rabbit Monoclonal Antibody from MyBioSource.com is a Rabbit Monoclonal antibody. This antibody recognizes Human antigen. The Anti-DR5 Rabbit Monoclonal Antibody has been shown to work in the following applications: Flow Cytometry, Immunoprecipitation, and Western Blot.
Description
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. Essential for ER stress-induced apoptosis