The KDM2B Antibody from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Human antigen. The KDM2B Antibody has been shown to work in the following applications: Western Blot.
Description
Description: Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Subunit Structure: Directly interacts with SKP1 and CUL1.
Similarity: The JmjC domain mediates demethylation activity (By similarity). It is also required for repression of ribosomal RNA genes. Belongs to the JHDM1 histone demethylase family