Rabbit Anti-Cytokeratin 10 Antibody MBS4380071 from MyBioSource.com

Product Specs
ItemRabbit Anti-Cytokeratin 10 Antibody
CompanyMyBioSource.com
Price $190.00Supplier Page View Company Product Page
Catalog NumberMBS4380071
Quantity0.02 mg (With BSA & Azide at 0.2mg/ml)
ClonalityMonoclonal
ReactivityHuman, Mouse. Others not known
Format200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml
ApplicationsFlow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin
SpeciesRabbit
Molecular Weight56.5kDa
TargetCytokeratin 10 (KRT10)
NCBI Full Gene Namekeratin 10
NCBI Gene AliasesKPP, K10, BIE, CK10, BCIE, EHK
Conjugate/TagUnconjugated
IsotypeIgG
CloneKRT10/1990R

Specifications/Features

This MAb recognizes a protein of 56.5kDa, identified as cytokeratin 10 (CK10). CK10 is expressed in all suprabasal layers of the epidermis. In the epidermis, expression of CK10 strictly parallels the extent of differentiation; it is absent in the basal layer, appears in the first suprabasal layers and increases in concentration towards the granular layer. However, CK10 is rarely detected in early stages of vulvar squamous carcinomas (tumors less than 2 cm, clinical stage I) regardless of the tumor grade. In larger and more advanced tumors (greater than 2 cm, clinical stages II and III), CK10 is detected very frequently. Expression of CK10 is related to maturation of malignant keratinocytes, being preferentially detected in more-differentiated parts

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