MyBioSource.com's Rabbit Anti-Claudin 7 Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, Immunohistochemistry, Immunoprecipitation, and Western Blot.
Description
The claudin superfamily consists of many structurally related proteins in humans. These proteins, which include claudin 1 through 18, are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Claudins, which consist of four trans-membrane domains and two extracellular loops, make up tight junction strands. Claudin 7 (CLDN7) has two isoforms, a full-length form with 211 aa residues and a C-terminal truncated form with 158 aa residues. This protein is localized in the intercellular junctions of the epithelial cells of the proximal tubules of the nephrons in mammalian kidney. It is expressed in normal human and mouse epithelia