Anti-TNIK antibody GTX13141 from GeneTex

Product Specs
ItemAnti-TNIK antibody
CompanyGeneTex
Price $419.00Supplier Page
Catalog NumberGTX13141
IsotypeIgG
HostRabbit
ClonalityPolyclonal
Quantity25 µl
ApplicationsWB, ICC/IF, IHC-P
Conjugate/TagUnconjugated
Antibody TypePrimary Antibodies
TargetTNIK
FormatPBS, 0.01% Sodium azide
ReactivityHuman, Mouse
Concentration1mg/ml
ImmunogenSynthetic peptide (unfortunately, the amino acid sequence is considered to be commercially sensitive)
NCBI Full Gene NameTRAF2 and NCK interacting kinase
PurityPurified by antigen-affinity chromatography
NCBI Gene AliasesTRAF2 and NCK interacting kinase, MRT54, MRT54
Research AreaCell Biology
Gene NameTNIK
Molecular Weight155

Questions and Answers

What applications has the Anti-TNIK antibody been shown to work in?

The Anti-TNIK antibody has been validated for use in Western Blotting, Immunocytochemistry, Immunofluorescence, and Immunohistochemistry.

Is there any research that highlights the role of TNIK in cancer?

Yes, TNIK has been identified as a potential therapeutic target in various cancers, including prostate cancer, lung squamous cell carcinoma, and gastric cancer. For instance, in prostate cancer, TNIK was found to be upregulated and correlated with ERG expression, suggesting its role in tumor growth and viability (). Additionally, in lung squamous cell carcinoma, TNIK inhibition demonstrated antitumor activity and increased apoptosis in patient-derived xenografts ().

Can the Anti-TNIK antibody be used in studies involving neuronal signaling?

Yes, the Anti-TNIK antibody has been utilized in studies investigating the JNK signaling pathway in neurons. Research has shown that TNIK, along with other kinases, regulates stress-induced JNK signaling, which is crucial for neuronal health and response to injury ().

What is the significance of TNIK amplification in cancer research?

TNIK amplification has been linked to tumor growth in various cancers, including gastric cancer, where it was shown to be essential for cell growth and survival. Silencing TNIK expression led to significant inhibition of cell growth in TNIK-amplified cell lines, indicating its potential as a novel therapeutic target ().

GeneTex

GeneTex, Inc. 2456 Alton Parkway

Irvine, California 92606

United States

Phone: 1-877-GeneTex (436-3839) or 949-553-1900
Fax: 949-309-2888

Company Profile

Website: http://www.genetex.com

(1) MAP4Ks inhibition promotes retinal neuron regeneration from Müller glia in adult miceNPJ Regenerative medicineJuly 13, 2023Zhang H, Guo Y, Yang Y, Wang Y, Zhang Y, Zhuang J, Zhang Y, Shen M, Zhao J, Zhang R, et al.AB_2140972), MAP4K6 (1:500, Novus, Cat. No. NBP1-22989, RRID: AB_1726507) and MAP4K7 (1:500, Genetex, Cat. No. GTX13141, RRID: AB_383061), JNK (1:1000, CST, Cat. No. #9252, RRID: AB_2250373), Phospho-JNK (1:1000, CST, Cat.

(2) CNK2 promotes cancer cell motility by mediating ARF6 activation downstream of AXL signallingNature communicationsJune 15, 2023Serwe G, Kachaner D, Gagnon J, Plutoni C, Lajoie D, Duramé E, Sahmi M, Garrido D, Lefrançois M, Arseneault G, et al.

(3) TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through MerlinCancer discoveryJune 1, 2021Torres-Ayuso P, An E, Nyswaner KM, Bensen RC, Ritt DA, Specht SI, Das S, Andresson T, Cachau RE, Liang RJ, et al.(#7077, 1:3000, RRID:AB_10694715) were purchased from Cell Signaling Technology. Antibody against TNIK (GTX13141, 1:1000, RRID:AB_383061) was purchased from GeneTex. Antibody against YAP/TAZ (63.7) was purchased from

(4) Extracellular matrix stiffness determines DNA repair efficiency and cellular sensitivity to genotoxic agentsScience advancesSeptember 1, 2020Deng M, Lin J, Nowsheen S, Liu T, Zhao Y, Villalta PW, Sicard D, Tschumperlin DJ, Lee S, Kim J, et al.Anti-Ubiquitin Antibody), MAP4K4 (Bethyl, A301-503A), MAP4K6 (Novus, NBP1-22990), MAP4K7 (Genetex, GTX13141), YAP/TAZ (Santa Cruz Biotechnology, sc-101199), V5 (Abcam, ab9116), pLATS1 T1079 (CST, 8654), LATS1

(5) Characterization of the ERG-regulated Kinome in Prostate Cancer Identifies TNIK as a Potential Therapeutic TargetNeoplasia (New York, N.Y.)April 1, 2019Lee RS, Zhang L, Berger A, Lawrence MG, Song J, Niranjan B, Davies RG, Lister NL, Sandhu SK, Rubin MA, et al.Western blot analysis using the following antibodies: ERG (Abcam, ab92513), ERG (Abcam, ab133264), TNIK (Genetex, GTX13141), TNIK (pS764) (Abgent, AP3276a), MERTK (Abcam, ab52968), MAP4K4 (Cell Signaling Technology, 3485),

(6) The Ste20 Family Kinases MAP4K4, MINK1, and TNIK Converge to Regulate Stress-Induced JNK Signaling in NeuronsThe Journal of neuroscience : the official journal of the Society for NeuroscienceNovember 15, 2017Larhammar M, Huntwork-Rodriguez S, Rudhard Y, Sengupta-Ghosh A, Lewcock JW.BioLegend, catalog #801203), anti-Mink1 (1:500; Novus, catalog #NBP1-22989), anti-TNIK (1:500; Genetex, catalog #GTX13141), anti-MAP4K4 (1:500; Cell Signaling Technology, catalog #3485), anti-cleaved-caspase-3 (1: 400; Cell Signaling Technology

(7) The essential role of TNIK gene amplification in gastric cancer growthOncogenesisFebruary 24, 2014Yu DH, Zhang X, Wang H, Zhang L, Chen H, Hu M, Dong Z, Zhu G, Qian Z, Fan J, et al.Antibodies used in this study were obtained from the following sources: TNIK (GeneTex, Irvine, CA, USA, Cat. GTX13141), phospho-Akt (S473) (Dako, Produktionsvej, Glostrup, Denmark Cat.M3628), phospho-Erk1/2 (Thr202/Tyr204)

(8) Traf2- and Nck-interacting kinase is essential for Wnt signaling and colorectal cancer growthCancer researchJune 15, 2010Shitashige M, Satow R, Jigami T, Aoki K, Honda K, Shibata T, Ono M, Hirohashi S, Yamada T.

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Anti-TNIK antibody

Anti-TNIK antibody

Anti-TNIK antibody

Anti-TNIK antibody

Anti-TNIK antibody from GeneTex

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Anti-TNIK antibody from GeneTex

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