CD32 (Fc Gamma RIIa) Antibody MBS4380898 from MyBioSource.com

Product Specs
ItemCD32 (Fc Gamma RIIa) Antibody
CompanyMyBioSource.com
Price $190.00Supplier Page View Company Product Page
Catalog NumberMBS4380898
ApplicationsFunctional Studies, Flow Cytometry (FC/FACS), Immunofluorescence (IF)
SpeciesMouse
IsotypeIgG2b kappa
CloneFCGR2A/479
ReactivityHuman (Hu)
Conjugate/TagUnconjugated
NCBI Gene AliasesFcGR, FCGR2A1, CD32A, FCGR2, CD32, IGFR2, FCG2, CDw32
NCBI Full Gene NameFc fragment of IgG receptor IIa
PurityPurified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
TargetCD32
Molecular Weight40kDa
Format200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml
ClonalityMonoclonal
Quantity0.02 mg (With BSA & Azide at 0.2mg/ml)

Specifications/Features

This MAb binds most strongly to the IIa isoforms of CD32 (FcRII), a type 1 transmembrane glycoprotein that mediates several functions including phagocytosis, cytotoxicity, and immunomodulation as well as platelet aggregation. Three genes (A, B, and C) encode CD32 and at least 6 isoforms are generated via alternative mRNA splicing, i.e., IIa1, IIa2, IIb1, IIb2, IIb3 and IIc. Monocytes/macrophages, placental trophoblasts and endothelial cells express all isoforms. In addition, the IIb isoform is expressed by B cells, and the IIa isoform by platelets, granulocytes and, weakly, by B cells. NK cells and neutrophils express Isoform IIc. CD32 binds weakly to the Fc region of monomeric IgG but more strongly to IgG aggregates and immune complexes

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