Mouse Anti-RAD51 Antibody MBS4380674 from MyBioSource.com

Product Specs
ItemMouse Anti-RAD51 Antibody
CompanyMyBioSource.com
Price $190.00Supplier Page View Company Product Page
Catalog NumberMBS4380674
Quantity0.02 mg (With BSA & Azide at 0.2mg/ml)
ClonalityMonoclonal
ReactivityHuman. Others not known
ApplicationsImmunohistology (Formalin-Fixed)
TargetRAD51
PurityPurified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
NCBI Full Gene NameRAD51 recombinase
NCBI Gene AliasesHsT16930, HsRad51, BRCC5, RECA, HRAD51, MRMV2, RAD51A, FANCR
IsotypeIgG1 kappa
CloneRAD51/2702
Conjugate/TagUnconjugated
Molecular Weight37kDa
SpeciesMouse
Format200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml

Specifications/Features

RAD51 is one of the key factors of DNA repair by homologous recombination and has been shown to have anti-apoptotic activity in tumor cells. RAD51 protein interacts with a variety of tumor suppressor proteins including p53, BRCA1 and BRCA2. Elevated expression of RAD51 enhances radio-resistance of human tumor cells. Overexpression of RAD51 protein in tumor cells renders them resistant against cytotoxic drugs like Cisplatin. RAD51 interacts with BRCA1 and BRCA2 to influence subcellular localization and cellular response to DNA damage. BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis from deregulation of RAD51. High-level expression of RAD51 has been observed in a variety of human malignancies. RAD51 overexpression correlates with histological grading of the tumor in invasive ductal mammary carcinoma

Add to Compare List