MyBioSource.com's FASL Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunocytochemistry, Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
Fas and Fas Ligand (FASL) belong to the TNF superfamily and are type I and type II transmembrane proteins, respectively. Binding of FASL to Fas triggers apoptosis in Fas-bearing cells. The mechanism of apoptosis involves recruitment of pro-caspase 8 through an adaptor molecule called FADD followed by processing of the pro-enzyme to active forms. These active caspases then cleave various cellular substrates leading to the eventual cell death. sFasR is capable of inhibiting FASL-induced apoptosis by acting as a decoy receptor that serves as a sink for FASL