The Rabbit Anti-Potassium Chloride Cotransporter Antibody from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Mouse, and Rat antigen. The Rabbit Anti-Potassium Chloride Cotransporter Antibody has been shown to work in the following applications: Western Blot.
Description
KCC2 is widely thought to be expressed exclusively in neurons where it is responsible for maintaining low intracellular chloride concentration to drive hyperpolarizing post-synaptic responses to the inhibitory neurotransmitters GABA and glycine (Lee et al., 2007). KCC2 is expressed in most adult neurons, and expression levels correlate well with the maturation state of neurons. N-ethylmaleimide (NEM) has been show to increase phosphorylation of the Ser940 residue, while decreasing phosphorylation of T1007 residue. Dephosphorylation of residues T906 and T1007 correlates with increased KCC2 activity (Moss et al., 2017)