The Anti-PKM2 Rabbit Monoclonal Antibody from MyBioSource.com is a Rabbit Monoclonal antibody. This antibody recognizes Human, Mouse, and Rat antigen. The Anti-PKM2 Rabbit Monoclonal Antibody has been shown to work in the following applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, and Western Blot.
Description
Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival