The STAT3 Mouse mAb Antibody from MyBioSource.com is a Mouse Monoclonal antibody. This antibody recognizes Human, Mouse, and Non-Human Primate antigen. The STAT3 Mouse mAb Antibody has been shown to work in the following applications: ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry, and Western Blot.
Description
The Stat3 transcription factor is an important signaling molecule for many cytokines and growth-factor receptors and is required for murine fetal development. Stat3 is constitutively activated in a number of human tumors and possesses oncogenic potential and anti-apoptotic activities. Stat3 is activated by phosphorylation at Tyr705, which induces dimerization, nuclear translocation and DNA binding. Transcriptional activation seems to be regulated by phosphorylation at Ser727 through the MAPK or mTOR pathways. Stat3 isoform expression appears to reflect biological function as the relative expression levels of Stat3alpha (86 kDa) and Stat3beta (79 kDa) depend on cell type, ligand exposure or cell maturation stage. It is notable that Stat3beta lacks the serine phosphorylation site within the carboxy-terminal transcriptional activation domain. Tissue specificity: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas