GDF-8/Myostatin Propeptide Antibody AF1539 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemGDF-8/Myostatin Propeptide Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $479.00Supplier Page View Company Product Page
Catalog NumberAF1539
NCBI Gene AliasesGdf8, GDF8, Cmpt, MSLHP
ApplicationsImmunoprecipitation,Western Blot,Neutralization
IsotypeIgG
Conjugate/TagUnconjugated
ReactivityHuman,Mouse,Transgenic Mouse
HostSheep
TargetGDF-8/Myostatin
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
Quantity100 ug (also 25 ug)
NCBI Full Gene Namemyostatin
ClonalityPolyclonal
ImmunogenMouse myeloma cell line NS0-derived recombinant mouse GDF-8/Myostatin Propeptide, Asn25-Ser265, Accession # O08689
ConcentrationLYOPH
PurityAntigen Affinity-purified
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Specificity: Detects GDF-8/Myostatin Propeptide in direct ELISAs and Western blots. In direct ELISAs, less than 10% cross-reactivity with mature recombinant mouse (rm) GDF-8 is observed and less than 5% cross-reactivity with mature rmGDF-1, -3, -5, -6, -7, -9, and recombinant human GDF-11 is observed.

Sizes Available: 100 ug (also 25 ug)

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Myostatin: a Circulating Biomarker Correlating with Disease in Myotubular Myopathy Mice and PatientsMolecular therapy. Methods & clinical developmentJune 12, 2020Koch C, Buono S, Menuet A, Robé A, Djeddi S, Kretz C, Gomez-Oca R, Depla M, Monseur A, Thielemans L, et al.antibody against DNM2 (1:250, clone 6A6, home-made), mouse GDF-8/Myostatin Propeptide (1:500, catalog #AF1539, R&D Systems), rabbit monoclonal anti-SMAD2/3 (1:2,000, catalog #04-914, Sigma Aldrich), rabbit polyclonal

(2) Blocking extracellular activation of myostatin as a strategy for treating muscle wastingScientific reportsFebruary 2, 2018Pirruccello-Straub M, Jackson J, Wawersik S, Webster MT, Salta L, Long K, McConaughy W, Capili A, Boston C, Carven GJ, et al.by SDS-PAGE followed by western blot with the following primary antibodies: anti-myostatin prodomain AF1539 (R&D Systems); anti-mature Myostatin ab124621 (Abcam). Immunoprecipitations with SRK-015, IgG control,

(3) The Use of Platelet-Rich and Platelet-Poor Plasma to Enhance Differentiation of Skeletal Myoblasts: Implications for the Use of Autologous Blood Products for Muscle RegenerationThe American journal of sports medicineMarch 1, 2017Miroshnychenko O, Chang WT, Dragoo JL.

(4) K153R polymorphism in myostatin gene increases the rate of promyostatin activation by furinFEBS lettersJanuary 30, 2015Szláma G, Trexler M, Buday L, Patthy L.[20]. Recombinant furin, recombinant BMP1, anti-Mouse Myostatin Propeptide sheep polyclonal antibody (AF1539) (R&D Systems, Minneapolis, MN, USA), alkaline phosphatase conjugated anti-sheep antibody (Sigma–Aldrich,

(5) Myostatin blockade with a fully human monoclonal antibody induces muscle hypertrophy and reverses muscle atrophy in young and aged miceSkeletal muscleJanuary 1, 2015Latres E, Pangilinan J, Miloscio L, Bauerlein R, Na E, Potocky TB, Huang Y, Eckersdorff M, Rafique A, Mastaitis J, et al.for immunoblotting; to visualize myostatin propeptide, an anti-propeptide sheep polyclonal antibody (AF1539; R&D Systems: Minneapolis, MN) was used. Human myostatin, growth and differentiation factor 11 (GDF11),

(6) A satellite cell-specific knockout of the androgen receptor reveals myostatin as a direct androgen target in skeletal muscleFASEB journal : official publication of the Federation of American Societies for Experimental BiologyJuly 1, 2014Dubois V, Laurent MR, Sinnesael M, Cielen N, Helsen C, Clinckemalie L, Spans L, Gayan-Ramirez G, Deldicque L, Hespel P, et al.

(7) Latent myostatin has significant activity and this activity is controlled more efficiently by WFIKKN1 than by WFIKKN2The FEBS journalAugust 1, 2013Szláma G, Trexler M, Patthy L.produced as described previously 22–31. Myostatin antibody (AF788) and myostatin propeptide antibody (AF1539) for western blots were from R&D Systems (Wiesbaden, Germany). Alkaline phosphatase-conjugated secondary

(8) Myostatin expression, lymphocyte population, and potential cytokine production correlate with predisposition to high-fat diet induced obesity in micePloS oneSeptember 22, 2010Lyons JA, Haring JS, Biga PR.| e12928 Myostatin and Inflammation were detected with anti-GDF8/myostatin prodomain antibody (AF1539, R&D Systems). Putative pro-myostatin (,50 kDa) and prodomain (,37 kDa) were detected in muscle, while

(9) Myostatin is upregulated following stress in an Erk-dependent manner and negatively regulates cardiomyocyte growth in culture and in a mouse modelPloS oneApril 19, 2010Bish LT, Morine KJ, Sleeper MM, Sweeney HL.(polyclonal) (1∶500, Millipore, AB3239, Temecula, CA); N-term myostatin (polyclonal) (R&D Systems, AF1539, Minneapolis, MN); phospho-Smad 2/3 (polyclonal) (1∶500, Millipore, Temecula, CA); Smad 2/3 (polyclonal)

(10) Targeting of bone morphogenetic protein growth factor complexes to fibrillinThe Journal of biological chemistryMay 16, 2008Sengle G, Charbonneau NL, Ono RN, Sasaki T, Alvarez J, Keene DR, Bächinger HP, Sakai LY.

(11) Muscular atrophy of caveolin-3-deficient mice is rescued by myostatin inhibitionThe Journal of clinical investigationNovember 1, 2006Ohsawa Y, Hagiwara H, Nakatani M, Yasue A, Moriyama K, Murakami T, Tsuchida K, Noji S, Sunada Y.

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GDF-8/Myostatin Propeptide Antibody

GDF-8/Myostatin Propeptide Antibody

GDF-8/Myostatin Propeptide Antibody

GDF-8/Myostatin Propeptide Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (11)

Reviews

GDF-8/Myostatin Propeptide Antibody from R&D Systems, a Bio-Techne Brand

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