ENaC alpha Antibody SPC-403D from StressMarq Biosciences Inc

Product Specs
ItemENaC alpha Antibody
CompanyStressMarq Biosciences Inc
Price $310.00Supplier Page View Company Product Page
Catalog NumberSPC-403D
Quantity100 µg
ApplicationsWB, IHC, ICC/IF, IP
Concentration1 mg/ml
Conjugate/TagUnconjugated
FormatAffinity Purified
ReactivityHuman, Rat, Mouse, Xenopus
TargetENaC alpha
HostRabbit
ImmunogenProduced against a synthetic peptide mapping to the N-terminal of the alpha subunit (amino acids 46-68) of rat Alpha ENaC (antibody designation 3560-2)
NCBI Full Gene Namesodium channel epithelial 1 subunit alpha
NCBI Gene AliasesENaCA
ClonalityPolyclonal
Research AreaNeuroscience, Neurotransmission, Ion Channels, Sodium Channels, Epithelial Sodium Channels (ENaC)

Questions and Answers

Can this antibody be used to study the role of ENaC in hypertension models?

Yes, the ENaC alpha antibody has been utilized in studies investigating hypertension, particularly in the context of angiotensin II-induced hypertension. For instance, it was shown that the activation of the (pro)renin receptor enhances α-ENaC expression, contributing to hypertension in mouse models ().

What applications has this antibody been shown to work in?

The ENaC alpha antibody has been demonstrated to be effective in various applications, including Western blotting, immunohistochemistry, immunoprecipitation, immunocytochemistry, and immunofluorescence, as evidenced by its use in multiple studies (, ).

Is this antibody suitable for use in different species?

Yes, the ENaC alpha antibody is reactive with multiple species, including human, mouse, rat, and Xenopus, making it versatile for comparative studies across different biological models ().

How has this antibody been utilized in research related to pregnancy and sodium retention?

The ENaC alpha antibody has been used to investigate the role of the (pro)renin receptor in pregnancy-induced sodium-water retention in rats, where it was found that α-ENaC expression is elevated during late pregnancy, contributing to fluid retention ().

StressMarq Biosciences Inc

117-1537 Hillside Ave.

Victoria, British Columbia V8T 4Y2

Canada

Phone: +1-250-294-9065
Fax: 1-250-294-9025

Email: info@stressmarq.com

Company Profile

Website: http://www.stressmarq.com

(1) Depletion of renal cortical collecting duct-secreted PCSK9 in early proteinuria prevents sustained nephrotic syndrome-related hypercholesterolemiaAmerican journal of physiology. Renal physiologyJune 1, 2026Molina-Jijon E, Zavala-Guevara IP, Gambut S, Gomez-Sierra T, Avila-Casado C, Macé C, Clement LC.

(2) The scaffold protein IQGAP1 regulates the epithelial Na(+) channelThe Journal of biological chemistryDecember 1, 2025Thines L, Shi S, Sayedyahossein S, Li Z, Roushar FJ, Kleyman TR, Sacks DB.

(3) Macula densa nitric oxide synthase 1β restoration by kidney alkalization enhances renal graft outcomesAmerican journal of physiology. Renal physiologySeptember 1, 2025Parris CL, Liu C, Rani A, Tran MH, Li M, Esquivel C, Oropeza A, Wang L.

(4) Intrarenal Generation of Aldosterone Contributes to Ischemia-Induced Hypertension and Nephropathy in MicebioRxivSeptember 1, 2025Ziwei Fu, Chang-Jiang Zou, Alex Kimball, Tianxin Yanganti-α-smooth muscle actin (α-SMA) antibody (cat no. ab5694; Abcam), rabbit anti-α-ENaC antibody (cat no. SPC-403D; Stressmarq Biosciences), and rabbit anti-GAPDH antibody (cat no. 5174S; Cell Signaling Technology).17

(5) Impact of hyperbaric oxygenation therapy (HBOT) on renal function in humanScientific reportsJuly 11, 2025Kanowski S, Shen Y, Klein T, Moeller MJ, Koch A, Theilig F.anti-NKCC2 (gift. S. Bachmann), sheep anti-NCC (S961B, University of Dundee), rabbit anti-αENaC (StressMarq, SPC-403D), rabbit anti-γENaC (StressMarq, SPC-405D), rabbit anti-GLUT1 (Merck Millipore, 07-1401), rabbit anti-NHE3

(6) Stable overexpression of the epithelial sodium channel alpha subunit reduces migration and proliferation in breast cancer cellsBreast cancer research and treatmentJune 1, 2025McQueen SRA, Chin WQ, Cunliffe HE, McDonald FJ.

(7) Ca(V)2.1 mediates presynaptic dysfunction induced by amyloid β oligomersCell reportsApril 22, 2025Jeans AF, Padamsey Z, Collins H, Foster W, Allison S, Dierksmeier S, Klein WL, van den Maagdenberg AMJM, Emptage NJ.

(8) Glucagon like peptide-1 modulates urinary sodium excretion in diabetic kidney disease via ENaC activationScientific reportsApril 3, 2025Kodama G, Taguchi K, Ito S, Nishino Y, Mori K, Taguchi S, Mitsuishi Y, Yamashita Y, Yamagishi SI, Fukami K.

(9) Collecting duct NCOR1 controls blood pressure by regulating mineralocorticoid receptorJournal of advanced researchFebruary 1, 2025Sun K, Wang YL, Hou CC, Shang D, Du LJ, Bai L, Zhang XY, Hao CM, Duan SZ.

(10) Case Report: Functional investigation of the γENaC G532S mutation presenting as mild PHA-1B3Frontiers in medicineJanuary 1, 2025Centonze E, Girish M, van Bemmelen MX, Staub O, Subramaniam G, Kellenberger S.

(11) Cross-sex hormone therapy in rats induces sex-specific adaptations of renal function and sodium transporters expressionFrontiers in physiologyJanuary 1, 2025Lichtenecker DCK, da Silva NB, Silveira IB, Monteiro LM, Argeri R, Dias Da Silva MR, Gomes GN.

(12) Bone marrow monocytes and macrophages from mice lacking βENaC and ASIC2 have a reduced chemotactic migration response and polarizationPhysiological reportsJuly 1, 2024Wasson R, Fleming AB, McLin J, Hildebrandt E, Drummond HA.

(13) Transport activity regulates mitochondrial bioenergetics and biogenesis in renal tubulesThe FASEB JournalMay 31, 2024Chih‐Jen Cheng, Jonathan M. Nizar, Dao‐Fu Dai, Chou‐Long Huanganti-Nkcc2 phospho-Thr-105 (Dundee Cat# S378C, 1:1000 dilution), anti-αENaC antibody (StressMarq Cat# SPC-403D, 1:2000 dilution), and anti-γENaC antibody (StressMarq Cat# SPC-405, 1:1000 dilution). The secondary

(14) Transport activity regulates mitochondrial bioenergetics and biogenesis in renal tubulesFASEB JMay 31, 2024Chih-Jen Cheng, Jonathan M Nizar, Dao-Fu Dai, Chou-Long Huanganti-Nkcc2 phospho-Thr-105 (Dundee Cat# S378C, 1:1000 dilution), anti-αENaC antibody (StressMarq Cat# SPC-403D, 1:2000 dilution), and anti-γENaC antibody (StressMarq Cat# SPC-405, 1:1000 dilution). The secondary

(15) Upregulation of α-ENaC induces pancreatic β-cell dysfunction, ER stress, and SIRT2 degradationJournal of biomedical researchMay 21, 2024Zhang X, Zhang D, Huo L, Zhou X, Zhang J, Li M, Su D, Sun P, Chen F, Liang X.

(16) Dietary sodium alters aldosterone's effect on renal sodium transporter expression and distal convoluted tubule remodellingThe Journal of physiologyMarch 1, 2024Mutchler SM, Hasan M, Murphy CP, Baty CJ, Boyd-Shiwarski C, Kirabo A, Kleyman TR.

(17) KDM6A Demethylase Regulates Renal Sodium Excretion and Blood PressureHypertension (Dallas, Tex. : 1979)March 1, 2024Han X, Akinseye L, Sun Z.

(18) Transport activity regulates mitochondrial bioenergetics and biogenesis in renal tubulesbioRxiv : the preprint server for biologyFebruary 8, 2024Cheng CJ, Nizar JM, Dai DF, Huang CL.

(19) The AE4 transporter mediates kidney acid-base sensingNature communicationsMay 26, 2023Vitzthum H, Koch M, Eckermann L, Svendsen SL, Berg P, Hübner CA, Wagner CA, Leipziger J, Meyer-Schwesinger C, Ehmke H.

(20) Two-generation exposure to a high-fat diet induces the change of salty taste preference in ratsScientific reportsApril 7, 2023Serirukchutarungsee S, Watari I, Narukawa M, Podyma-Inoue KA, Sangsuriyothai P, Ono T.min. The sections were blocked by incubation with 3% BSA in TBST for 2 h and incubated with ENaCα (SPC403D, StressMarq Biosciences, Canada; 1:1000) overnight at 4°C. Subsequent procedures were performed using

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ENaC alpha Antibody

ENaC alpha Antibody

ENaC alpha Antibody

ENaC alpha Antibody

ENaC alpha Antibody from StressMarq Biosciences Inc

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ENaC alpha Antibody from StressMarq Biosciences Inc

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