Ultra-LEAF™ Purified anti-mouse CD4 100458 from BioLegend

Product Specs
ItemUltra-LEAF™ Purified anti-mouse CD4
CompanyBioLegend
Price $1,408.00Supplier Page View Company Product Page
Catalog Number100458
Quantity25MG
ApplicationsFC,Block,Costim,Depletion,IHC,IP
Conjugate/TagUnconjugated
Format0.2 µm filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is <0.01 EU/µg of the protein (<0.001 ng/µg of the protein) as determined by the LAL test
ReactivityMouse
TargetCD4
IsotypeRat IgG2b, κ
CloneGK1.5
HostRat
Antibody TypePrimary
ImmunogenMouse CTL clone V4
NCBI Full Gene NameCD4 antigen
NCBI Gene AliasesL3T4, Ly-4
ClonalityMonoclonal

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BioLegend

8999 BioLegend Way

San Diego, California 92121

United States

Phone: 1-877-246-5343 Toll-Free, USA & Canada
1-858-768-5800 International
Fax: 1-877-455-9587

Company Profile

Website: biolegend.com

(1) FAP-CD40 and PD1-IL2v combination therapy reprograms immunologically cold tumors through de novo intratumoral T cell-dendritic cell clustersJournal for ImmunoTherapy of CancerMay 28, 2026Thuy Trinh Nguyen, Harold Gómez, Mechthild Lutge, Emilio Yángüez, Tamara Hüsser, Sina Nassiri, Christine Trumpfheller, Sara Colombetti, Laura Codarri Deak, Pablo Umaña, et al.depletion in vivo For CD4+ and/or CD8+ T cell depletion, anti-mouse CD4 (clone “GK1.5”, BioLegend, #100470) and anti-mouse CD8α (clone “2.43”, Selleck Chemicals, #A2102-5MG*20) antibodies were diluted in Histidine

(2) Citalopram exhibits immune-dependent anti-tumor effects by modulating C5aR1+ TAMseLifeFebruary 9, 2026Fangyuan Dong, Shan Zhang, Kaiyuan Song, Luju Jiang, Li-Peng Hu, Qing Li, Xue-Li Zhang, Jun Li, Mingxuan Feng, Zhi-Wei Cai, et al.Antibody, Biolegend, Cat #100763; and Ultra-LEAF Purified anti-mouse CD4 Antibody, Biolegend, Cat #100457) the day before the implantation of cancer cells and then with 100 µg twice a week for the entire duration

(3) Citalopram exhibits immune-dependent anti-tumor effects by modulating C5aR1+ TAMsElifeFebruary 9, 2026Fangyuan Dong, Shan Zhang, Kaiyuan Song, Luju Jiang, Li-Peng Hu, Qing Li, Xue-Li Zhang, Jun Li, Mingxuan Feng, Zhi-Wei Cai, et al.Antibody, Biolegend, Cat #100763; and Ultra-LEAF Purified anti-mouse CD4 Antibody, Biolegend, Cat #100457) the day before the implantation of cancer cells and then with 100 µg twice a week for the entire duration

(4) Pharmacological rescue of mutant p53 triggers spontaneous tumor regression via immune responsesCell Reports MedicineMarch 18, 2025Jiabing Li, Shuang Zhang, Baohui Wang, Yuting Dai, Jiale Wu, Dianjia Liu, Ying Liang, Shujun Xiao, Zhengyuan Wang, Jiaqi Wu, et al.anti-rabbit immunoglobulin,Servicebio,Cat# GB23303; RRID: AB_2811189 CD4+ depletion antibody,BioLegend,Cat# 100457; RRID: AB_2810318 CD8+ depletion antibody,BioLegend,Cat# 100763; RRID: AB_2810323 IFN-γ depletion

(5) Interleukin-16 enhances anti-tumor immune responses by establishing a Th1 cell-macrophage crosstalk through reprogramming glutamine metabolism in miceNature communicationsMarch 10, 2025Wen Z, Liu T, Xu X, Acharya N, Shen Z, Lu Y, Xu J, Guo K, Shen S, Zhao Y, et al.performed twice a week. T cell depletion For CD4+ T cell depletion, 200 μg CD4 antibody (Biolegend, #100457) was i.p. injected into mice twice a week, starting from day 0 after tumor inoculation. IFN-γ neutralization For

(6) Synthetic short mRNA prevents metastasis via innate-adaptive immunityNat CommunFebruary 25, 2025Hikaru Hayashi, Sayaka Seki, Takeshi Tomita, Masayoshi Kato, Norihiro Ashihara, Tokuhiro Chano, Hideki Sanjo, Miwa Kawade, Chenhui Yan, Hiroki Sakai, et al.μg/mL). Mouse in vivo: Anti-asialo GM1 (Wako, 014-09801, 50 μL/animal); Anti-mouse CD4 (BioLegend, 100457, 250 μg/animal); Anti-mouse CD8a (BioLegend, 100763, 250 μg/animal). Human cell sorting: PE anti-human CD56 (NCAM

(7) VSIG4+ tumor-associated macrophages mediate neutrophil infiltration and impair antigen-specific immunity in aggressive cancers through epigenetic regulation of SPP1J Exp Clin Cancer ResFebruary 7, 2025Zongfu Pan, Jinming Chen, Tong Xu, Anqi Cai, Bing Han, Ying Li, Ziwen Fang, Dingyi Yu, Shanshan Wang, Junyu Zhou, et al.subcutaneously. Then, mice were intraperitoneally injected with 100 µg anti-CD4 (GK1.5) antibody (Biolegend, 100458), 50 µg anti-NK-1.1 (PK136) antibody (Biolegend, 108760), and 100 µg anti-CD8a (53-6.7) antibody (Biolegend,

(8) In situ endoscopic photodynamic therapy combined with immature DC vaccination induces a robust T cell response against peritoneal carcinomatosisJournal for immunotherapy of cancerNovember 5, 2024Degavre C, Lepez A, Ibanez S, François C, Głowacka K, Guilbaud C, Laloux-Morris F, Esfahani H, Brusa D, Bouzin C, et al.

(9) Antiviral innate immune memory in alveolar macrophages following SARS-CoV-2 infection ameliorates secondary influenza A virus diseaseImmunityNovember 1, 2024Alexander Lercher, Jin-Gyu Cheong, Michael J. Bale, Chenyang Jiang, Hans-Heinrich Hoffmann, Alison W. Ashbrook, Tyler Lewy, Yue S. Yin, Corrine Quirk, Emma J. DeGrace, et al.cells via intraperitoneally administration of two doses of 200μg of anti-CD4 (clone GK1.5, Biolegend #100458) and anti-CD8a (clone 2.43, BioXCell #BE00061) 8 and 5 days prior transfer. Airway-resident macrophages

(10) Cytotoxic T cells drive doxorubicin-induced cardiac fibrosis and systolic dysfunctionNature Cardiovascular ResearchJuly 17, 2024Abraham L. Bayer, Maria A. Zambrano, Sasha Smolgovsky, Zachary L. Robbe, Abul Ariza, Kuljeet Kaur, Machlan Sawden, Anne Avery, Cheryl London, Aarti Asnani, et al.depletion, mice were given 100 μg of anti-CD8 antibody (Biolegend, 100763) or anti-CD4 antibody (Biolegend, 100457) by intraperitoneal injection every 4 days starting 2 days before the first DR injection. For adoptive transfer

(11) Interaction of an α-synuclein epitope with HLA-DRB1(∗)15:01 triggers enteric features in mice reminiscent of prodromal Parkinson's diseaseNeuronNovember 1, 2023Garretti F, Monahan C, Sloan N, Bergen J, Shahriar S, Kim SW, Sette A, Cutforth T, Kanter E, Agalliu D, et al.250 μg of Ultra-LEAF Purified anti-mouse CD4 or Rat IgG2b isotype control antibodies (Biolegend, Cat #100457 and Cat #400644; San Diego, CA) 3 and 1 days prior to immunization. After immunization, mice were injected

(12) CD4(+) T cells aggravate hemorrhagic brain injuryScience advancesJune 9, 2023Shi SX, Xiu Y, Li Y, Yuan M, Shi K, Liu Q, Wang X, Jin WN.experimental conditions. Administration of monoclonal antibodies Ultra-LEAF–purified anti-CD4 mAb (100470, GK1.5, BioLegend, San Diego, CA) was intraperitoneally injected to deplete CD4+ T cells, with a dose

(13) Alveolar macrophages instruct CD8(+) T cell expansion by antigen cross-presentation in lungCell reportsDecember 13, 2022Kawasaki T, Ikegawa M, Yunoki K, Otani H, Ori D, Ishii KJ, Kuroda E, Takamura S, Kitabatake M, Ito T, et al.

(14) Ultrasound combined with nanobubbles promotes systemic anticancer immunity and augments anti-PD1 efficacyJournal for immunotherapy of cancerMarch 1, 2022Hu J, He J, Wang Y, Zhao Y, Fang K, Dong Y, Chen Y, Zhang Y, Zhang C, Wang H, et al.of cellular subsets in vivo were carried out using antibodies against CD8 (100764, BioLegend), CD4 (100458, BioLegend) and NK1.1 (108759, BioLegend). Ex vivo coculture assay A total of 1×107 splenocytes from

(15) CXCL13 expression in mouse 4T1 breast cancer microenvironment elicits antitumor immune response by regulating immune cell infiltrationPrecision clinical medicineSeptember 1, 2021Ma Q, Chen Y, Qin Q, Guo F, Wang YS, Li D.

(16) CTLA-4 expression by B-1a B cells is essential for immune toleranceNature communicationsJanuary 22, 2021Yang Y, Li X, Ma Z, Wang C, Yang Q, Byrne-Steele M, Hong R, Min Q, Zhou G, Cheng Y, et al.

(17) CD49a Regulates Cutaneous Resident Memory CD8⁺ T Cell Persistence and ResponseCell reportsSeptember 1, 2020Bromley SK, Akbaba H, Mani V, Mora-Buch R, Chasse AY, Sama A, Luster AD.RESOURCE,SOURCE,IDENTIFIER Antibodies,, Ultra-Leaf Purified anti-mouse CD4 (GK1.5),Biolegend,Cat# 100458; RRID AB_2810319 InVivoMab anti-mouse CD8α (YTS169.4),BioXCell,Cat# BE0117; RRID AB_10950145 Ultra-Leaf Purified anti-mouse CD28

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Ultra-LEAF™ Purified anti-mouse CD4 from BioLegend

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Ultra-LEAF™ Purified anti-mouse CD4 from BioLegend

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