Fig 1: Baicalin prevents iohexol-induced pyroptosis of HK-2 cells by regulating inflammasome release. HK-2 cells were transfected with negative control siRNA (siNC) or NLRP3 siRNA (siNLRP3), Caspase-1 siRNA (siCaspase-1). (A) The expression levels of NLRP3, ASC, Caspase-1 and GSDMD were detected by Western blotting. (B) Related quantification of NLRP3, ASC, Caspase-1 and GSDMD by grayscale analysis. a~cMeans with the different letters are significantly different (p<005) by Duncan’s multiplerange tests.