PMEL17/SILV Antibody (PMEL/1825R) [Alexa Fluor® 594] from Novus Biologicals, a Bio-Techne Brand

Available conjugates: Available conjugates: Alexa Fluor 350, Alexa Fluor 405, DyLight 594, Alexa Fluor 647, FITC, Alexa Fluor 532, DyLight 350, Janelia Fluor 646, DyLight 650, Alexa Fluor 700, DyLight 550, DyLight 405, Alexa Fluor 594, Alexa Fluor 488, Janelia Fluor 549, DyLight 488, DyLight 755, Alexa Fluor 750, Biotin

Specificity: The gp100 molecule is a 100kDa glycosylated protein that is cleaved into a small (26kDa) carboxy-terminal fragment and a larger amino- terminal section (60 64 kDa), which is subsequently cleaved to generate 26kDa and 34 38kDa fragments. By immunohistochemistry, it specifically recognizes a protein in melanocytes and melanomas. This monoclonal antibody reacts with junctional and blue nevus cells and variably with fetal and neonatal melanocytes. Intradermal nevi, normal adult melanocytes, and non-melanocytic cells are negative. It does not stain tumor cells of epithelial, lymphoid, glial, or mesenchymal origin. Metastatic amelanotic melanoma can often be confused with a variety of poorly differentiated carcinomas, large cell lymphomas, and sarcomas using H E stains alone. It is also difficult to differentiate melanoma from spindle cell carcinomas and various types of mesenchymal neoplasms. This monoclonal antibody stains fetal and neonatal melanocytes, junctional and blue nevus cells, and malignant melanoma. This monoclonal antibody also stains Angiomyolipoma (PEComa).

Sizes Available: 0.1 ml