Phospho-CREB (Ser133) (87G3) Rabbit mAb 9198S from Cell Signaling Technology

Product Specs
ItemPhospho-CREB (Ser133) (87G3) Rabbit mAb
CompanyCell Signaling Technology
Price $401.00 Inquire
Catalog Number9198S
Quantity100 µl
ApplicationsW, W-S, IHC-P, IF-F, IF-IC, FC-FP, ChIP, ChIP-seq, C&R, C&T
ReactivityH, M, R
TargetCREB (Ser133) phosphate
ModificationsCREB (Ser133) phosphate
HostRabbit
NCBI Gene AliasesCREB, CREB-1
ClonalityMonoclonal
NCBI Full Gene NamecAMP responsive element binding protein 1
Research AreaNeuroscience
IsotypeIgG
Clone87G3
Molecular Weight43

Questions and Answers

Can this antibody be used to study CREB signaling in neurodegenerative conditions?

Yes, the Phospho-CREB (Ser133) Rabbit mAb has been utilized in studies investigating CREB signaling in neurodegenerative contexts. For instance, it was employed in research examining the role of Notch1 in hippocampal plasticity, where CREB activation was shown to be crucial for synaptic potentiation and memory formation ().

Is this antibody effective for detecting phosphorylated CREB in cancer research?

The antibody has been shown to work effectively in cancer research, as evidenced by its use in studies exploring the role of TRPM2 in neuroblastoma. In this context, the antibody was used to assess the phosphorylation status of CREB, which is involved in the regulation of integrin expression and cell migration in cancer cells ().

What applications has this antibody been validated for in scientific research?

The Phospho-CREB (Ser133) Rabbit mAb has been validated for use in various applications including Western blotting, immunofluorescence, and chromatin immunoprecipitation. It has been cited in multiple studies that utilized these techniques to investigate CREB phosphorylation and its downstream effects (, ).

Does this antibody have cross-reactivity with other proteins?

The antibody specifically detects phosphorylated CREB at serine 133 and has also been shown to recognize the phosphorylated form of the CREB-related protein, ATF-1. This specificity is important for studies focusing on the distinct roles of these proteins in cellular signaling pathways ().

Cell Signaling Technology

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Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) High sucralose exposure in early pregnancy increases the susceptibility of heart defects in mice offspringiScienceMay 15, 2026Zehua Zhang, Ziwen Yu, Haiqun Shi, Tong Ding, Yan Shi, Jianyuan Zhao, Ke Cai, Feng WangRESOURCE,SOURCE,IDENTIFIER Antibodies,Antibodies,Antibodies ,, Phospho-CREB (Ser133),Cell Signaling Technology,Cat# 9198; RRID: AB_2561044 CREB,Cell Signaling Technology,Cat# 9197; RRID: AB_331277 TAS1R3,ABclonal,Cat# A10157;

(2) Effects of increasing intranuclear calcium levels via MCU inhibition on mouse and human PSC-derived cardiomyocyte differentiation and maturationStem Cells Transl MedApril 27, 2026Hyun Ju Seo, Ju-Young Kim, Hyun-Jai Cho, Joo-Eun Lee, Sang-Beom Bang, Mika Jeon, Hyang-Ae Lee, Yoo-Jeong Shin, Han-Mo Yang, Hyo-Soo Kimthe transcription factor expression levels using the phospho-CREB (Ser133; 87G3) rabbit monoclonal (#9198; Cell Signaling Technology), CREB (48H2) rabbit monoclonal (#9197; Cell Signaling Technology), anti-SERCA2

(3) Combined Inhibition of TRPM4/NMDA Receptor Complex and Extrasynaptic NMDA Receptors Is Candidate Therapeutic Target for Suppression of Epileptic Seizures and Improvement of Cognitive ImpairmentsPharmacol Res PerspectApril 24, 2026Motohiro Okada, Ruri Okubo, Tomoka Oka, Eishi Motomuraelement binding protein (CREB) (#4820, 1:50, Cell Signaling Technology, Danvers, MA, USA), and pCREB (#9198, 1:50, Cell Signaling) were used. Target protein sizes were determined for each sample in comparison

(4) The Antidepressant Amitriptyline Upregulates ERK1/2 Signaling and Inhibits Rho-Mediated Responses Induced by Lysophosphatidic Acid in Astroglial CellsInt J Mol SciApril 20, 2026Maria C. Olianas, Simona Dedoni, Pierluigi Onali(Sc-365876, Santa Cruz Biotechnology) (1:1000), rabbit monoclonal anti-phospho-CREB (Ser133) (cat. no. 9198, Cell Signaling Technology) (1:1000), rabbit monoclonal anti-CREB (cat. no. 9197, Cell Signaling Technology)

(5) Dietary Yam (Dioscorea opposita Thunb.) Ameliorates Parkinson’s Disease in Mice via Gut Microbiota-Driven Mitochondrial Improvement and Neuroinflammation InhibitionNutrientsApril 11, 2026Shuqing Zhang, Wenjia Pan, Chen Ma, Yinghua Luo, Li Dong, Junfu Ji, Lingjun Ma, Daotong Li, Fang ChenProteintech, Wuhan, China, 1:1000), PGC1α (NBP1-04676, Novus Biologicals, Centennial, CO, USA, 1:500), p-CREB (9198, CST, Danvers, MA, USA, 1:1000), CREB (9197, CST, Danvers, MA, USA, 1:1000), NLRP3 (ab263899, Abcam,

(6) Ethanolic Extract of Padina arborescens Suppresses Melanogenesis and Attenuates UVB-Induced Photodamage in Cellular and Zebrafish ModelsInt J Mol SciApril 9, 2026Yun-Su Lee, Wook-Chul Kim, Kyeong Min Lee, Seo-Rin Jung, Seung Tae Im, Min-Cheol Kang, Seung-Hong Leecatalytic subunit (Thr197) (p-PKA C, #4781), total PKA C-α (#4782), phosphorylated CREB (Ser133) (p-CREB, #9198), total CREB (#9197), and MITF (D3B4T, #97800) were purchased from Cell Signaling Technology (Danvers,

(7) Timosaponin AIII enhances CAR-T cell potency and prevents relapse through impairing CAR-TregsNature CommunicationsMarch 31, 2026Mingqi Hou, Wenjun Zhang, Ziping Qi, Guiming Li, Husheng Mei, Shuang Qi, Rui Jin, Yuedong Zhao, Xiaochen Tang, Bing Xiu, et al.CREB (Cell Signaling Technology, 9197 T, 1:1000), phospho-CREB (Ser133; Cell Signaling Technology, 9198 T, 1:1000), A2AR (Santa Cruz Biotechnology, sc-32261, 1:1000), and GAPDH (Cell Signaling Technology,

(8) Centella asiatica ameliorates scopolamine-induced cognitive impairment via acetylcholinesterase modulation and oxidative stress reductionFood Science and BiotechnologyMarch 25, 2026Yeon-Ji Kim, Yun-Mi Kang, Malk Eun Pak, Hee Jin Eom, Kwang Youn Kim, Nayon Hur, Youngha Seo, Tae Kyu Oh, JaeWoo Bae, Jae Kyoung Lee, et al.Danvers, MA, USA), BDNF (#47,808, Cell Signaling Technology, Danvers, MA, USA), anti-phosphorylated-CREB (#9198, Cell Signaling Technology, Danvers, MA, USA), and anti-CREB (#9197, Cell Signaling Technology, Danvers,

(9) GPER1 reduces skin inflammation by inhibiting keratinocyte proliferationCell Death DiscoveryMarch 21, 2026Natalia Pérez-Escudero, Isabel Cabas, Raúl Corbalán-Vélez, Teresa Martínez-Menchón, Belén Ferri, María L. Cayuela, Diana García-Moreno, Alfonsa García-Ayala, Victoriano MuleroGPER1 (Sigma-Aldrich, #SAB2700363, 1/100), or rabbit monoclonal anti-pCREB (Cell Signaling Technology, #9198, 1/800), followed by 1/100 dilution of biotinylated anti-rabbit secondary antibody (Dako, E0432) and

(10) Transient SUMOylation inhibition in human pre-adipocytes stably imprints a transcriptional beiging fateNucleic Acids ResMarch 19, 2026Patrizia Maria Christiane Nothnagel, Paul-Arthur Meslin, Jonas Aakre Wik, Damien Dufour, Yunna Erika Strøm, Magnar Bjørås, Jorrit Martijn Enserink, Bjørn Steen Skålhegg, Nolwenn Briand, Anthony Mathelier, et al.UCP1, abcam, ab209483; PKA phospho-substrates, Cell Signaling, 9624; p-CREB/p-ATF1, Cell Signaling, 9198; p38 MAPK, Cell Signaling, 9212; p-p38 MAPK, Cell Signaling, 9211; p-ATF2, Cell Signaling, 24329; SUMO2/3,

(11) C/EBPβ dictates postmenopausal FSHβ transcription and blockade of AEP/C/EBPβ pathway alleviates osteoporosisBone ResMarch 17, 2026Zhongyun Xie, Jianming Liao, Jing Xiong, Zhenlei Zhao, Keqiang Yefor western blotting), CREB (catalog#: 9197 T, 1:1 000 for western blotting) and p-CREB (catalog#: 9198 T, 1:1 000 for western blotting) were purchased from Cell Signaling Technology; Antibody to TrkB (catalog#:

(12) Salidroside Selectively Binds to SEC23A and Ameliorates Psychological Stress-Induced HyperpigmentationPharmaceuticals (Basel)March 16, 2026Man Yang, Xiaoyu Sun, Da Wang, Huizhong Nie, Kang Cheng, Jie Gu, Lu Chen, Yuxuan Zhang, Lingli Yang, Ichiro Katayama, et al.anti-glyceraldehyde 3-phosphate dehydrogenase (GAPDH; Abcam, ab8245); anti-p-CREB (Cell Signaling Technology, 9198); anti-CREB (Cell Signaling Technology, 9197, Massachusetts, MA, USA); anti-β-catenin (Cell Signaling Technology

(13) Reduced glycoprotein hormone β-5 links male aging and testosterone decline to increased adiposityJournal of Clinical InvestigationMarch 16, 2026Gengmiao Xiao, Aijun Qian, Zhuo Gao, Tingting Dai, Hui Liang, Shuai Wang, Mulan Deng, Yunjing Yan, Xindan Zhang, Xuedi Zhang, et al.(Cell Signaling Technology, 2213S), CREB (Cell Signaling Technology, 9197S), phospho-CREB (Cell Signaling Technology, 9198S), GAPDH (Cell Signaling Technology, 2118S), or β-actin (Sigma, A5316). Reactive bands were visualized

(14) Fluoxetine Repurposing Mitigates Alzheimer's Disease Pathology via the GSK3β-CREB-ADAM10 AxisInt J Mol SciMarch 14, 2026Soo-Ho Lee, Yeonghoon Son, Hyosun Jang, Hyun-Yong Kim, Kwang Seok Kim, Hyun-Shik Lee, Hae-June Lee(Cell Signaling Technology, Danvers, MA, USA; #9197, 1:1000), anti-p-CREB (Cell Signaling Technology; #9198, 1:1000), GSK-3β (Cell Signaling Technology; #9315, 1:1000), anti-p-GSK-3β (Cell Signaling Technology;

(15) Prebiotics attenuate depressive-like behavior, neuroinflammation and synaptic plasticity in Parkinson’s disease by modulating butyrate-producing gut bacteriaInflammopharmacologyMarch 13, 2026Ingrid Prata de Mendonça, Rodrigo Soares da Silva, Igor Henrique Rodrigues de Paiva, Belmira Lara da S. A. Costa, Karla Patrícia de Sousa Barbosa Teixeira, José Roberto Botelho de Souza, Christina Alves Peixotoprimary antibodies anti-tyrosine hydroxylase (Invitrogen OPA1-0405, 1:500), p-CREB (Cell Signaling, #9198, dilution 1:500), BDNF (Alomone Labs, ANT-010, dilution 1:300), IBA-1 (Wako, 019-19741, dilution 1:500)

(16) Palmitoylation-mediated regulation of KAT2A promotes lung metastasis in breast cancerNature Cell BiologyMarch 13, 2026Ming Liu, Anke Vandekeere, Xiao-Zheng Liu, Stephan Schenck, Juan Fernández-García, Tine Tricot, Yiming Peng-Winkler, Margherita Demicco, Dorien Broekaert, Ines Vermeire, et al.membrane marker staining. The spheroids were then incubated with phosphor-STAT3 (PY705, Cell Signaling 9198; 1:200 dilution) or STAT3(Proteintech 10253-2-AP; 1:200 dilution)) antibodies overnight at 4°C, washed

(17) Neuroprotective Effect of the Combined Extract of Mentha piperita and Cornus officinalis Against Neuronal Cell Death and Scopolamine-Induced Memory ImpairmentInt J Mol SciMarch 9, 2026Kang-Il Oh, Junhwan Jeong, Hyesoo Jeong, Yoonjoong Yong, Subin Yeo, Eunkuk Park, Seon-Yong JeongCell Signaling Technology), p-ERK (#9101; Cell Signaling Technology), t-CREB (#9197; Cell Signaling Technology), p-CREB (#9198; Cell Signaling Technology), and β-actin (sc-47778; Santa Cruz Biotechnology, Dallas, TX, USA). Thereafter,

(18) MYO1C is a urinary extracellular vesicle biomarker and mediator of podocyte injury in diabetic nephropathyJCI InsightMarch 9, 2026Zihao Zhao, Qianqian Yan, Sijie Zhou, Fengxun Liu, Yong Liu, Jingjing Ren, Shaokang Pan, Zhenjie Liu, Dongwei Liu, Zhangsuo Liu, et al.cleaved caspased-3 (9661S, CST), desmin (sc23879, Santa), p38(8690S, CST), p-p38(4511S, CST), and p-CREB(9198S, CST). GAPDH (Goodhere Biotechnology) was used as the loading control. Secondary antibodies were purchased

(19) GLUD1 supports ovarian cancer progression by counteracting anoikis via ARAF/MEK/ERK signalingnpj Precision OncologyMarch 5, 2026Huolun Feng, Yanzhen Chen, Geyan Wu, Zhentao Zhang, Hongkun Lai, Changnian Yang, Shaofen Zhang, Yongqing Lin, Yingqi Liu, Haiyan Ye, et al.antibody, p-AMPK(1:1000, Cat# 2535 T) antibody, CREB(1:1000, Cat# 9197 T) antibody, p-CREB(1:1000, Cat# 9198 T), and BCL-2 (1:1000, Cat# 15071 T) were purchased from Cell Signaling Technology (Danvers, MA, USA).

(20) Restricting Synaptotagmin-3 Internalization Mitigates Cerebral Ischemia/Reperfusion Injury by Curtailed Neuronal Apoptosis and Microglial Re-ProgrammingCNS Neurosci TherMarch 5, 2026Hua Xu, Hongbo Mi, Rong Cheng, Tiantian Gui, Fangzhou Hu, Yi Yang, Jian Cheng, Qun Xue(p‐PKA, 1:1000, AF7246, Affinity), PKA (1:1000, AF7746, Affinity), phospho‐CREB Ser133 (p‐CREB, 1:1000, 9198, CST) and CREB (1:1000, 9197, CST). After washing with TBST or PBST, the PVDF membranes were subsequently

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Phospho-CREB (Ser133) (87G3) Rabbit mAb

Phospho-CREB (Ser133) (87G3) Rabbit mAb from Cell Signaling Technology

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Phospho-CREB (Ser133) (87G3) Rabbit mAb from Cell Signaling Technology

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