Phospho-PDGF Receptor alpha (Tyr754) (23B2) Rabbit mAb 2992S from Cell Signaling Technology

Product Specs
ItemPhospho-PDGF Receptor alpha (Tyr754) (23B2) Rabbit mAb
CompanyCell Signaling Technology
Price $397.00 Inquire
Catalog Number2992S
Quantity100 µl
ApplicationsW, IP
ReactivityH, M
TargetPDGFR-a (Tyr754) phosphate
ModificationsPDGFR-a (Tyr754) phosphate
HostRabbit
NCBI Gene AliasesCD140A, PDGFR-2, PDGFR2
ClonalityMonoclonal
NCBI Full Gene Nameplatelet derived growth factor receptor alpha
Research AreaRTK
Clone23B2
IsotypeIgG
Molecular Weight190

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Aberrant coupling of glutamate and tyrosine kinase receptors enables neuronal control of brain-tumor growthNeuronNovember 5, 2025Corina Anastasaki, Rui Mu, Chloe M. Kernan, Xuanwei Li, Rasha Barakat, Joshua P. Koleske, Yunqing Gao, Olivia M. Cobb, Xinguo Lu, Charles G. Eberhart, et al.(Tyr653/654),Cell Signaling Technologies,Cat# 52928S Phospho-PDGFRa,Cell Signaling Technologies,Cat# 2992S Phospho-S6,Cell Signaling Technologies,Cat# 2215S Phospho-Src,Cell Signaling Technologies,Cat# 6943S Phospho-TRKB

(2) Exploiting collateral sensitivity in the evolution of resistance to tyrosine kinase inhibitors in soft tissue sarcomasCommun BiolAugust 8, 2025Mark L. Elms, Andrew D. Jenks, Avirup Chowdhury, Lukas Krasny, Madhumeeta Chadha, Kaan Low, Peter T. Harrison, William G. Kerrison, Robin L. Jones, Paul H. HuangCell Signalling Technology; 4695), rabbit anti-pPDGFRA (Y754) (1:500; 23B2; Cell Signalling Technology; 2992), rabbit anti-pPDGFRA (Y1018) (1:500; Cell Signalling Technology; 4547), rabbit anti-PDGFRA (1:1000;

(3) Effective targeting of PDGFRA-altered high-grade glioma with avapritinibCancer CellApril 14, 2025Lisa Mayr, Sina Neyazi, Kallen Schwark, Maria Trissal, Alexander Beck, Jenna Labelle, Sebastian K. Eder, Liesa Weiler-Wichtl, Joana G. Marques, Carlos A.O. de Biagi-Junior, et al.,Cell Signaling Technologies,Cat# 3174; RRID:AB_2162345 anti-phosphorylated-PDGFRA (Y754),Cell Signaling Technologies,Cat# 2992; RRID:AB_390728 anti-S6,Cell Signaling Technologies,Cat# 2217; RRID:AB_331355 anti-phosphorylated-S6

(4) Dyr726, a brain-penetrant inhibitor of PI3Kα, Type III receptor tyrosine kinases, and WNT signallingbioRxivMarch 31, 2025Vasudha Tandon, Alessandra Hope Fistrovich, Joaquina Nogales, Febe Ferro, Samantha N Rokey, Carly Rose Cabel, Amy Dunne Miller, Mary Yagle, Christina Duncan, Aditi Atmasidha, et al.3391 Anti-PDGFR,Cell Signaling Technology,Cat#: 3174 Anti-p-PDGFR (Tyr754),Cell Signaling Technology,Cat#: 2992 Goat Anti-Rabbit IgG (H + L)-HRP Conjugate,BioRad,Cat#: 1706515 "Goat anti-Mouse IgG (H+L), HRP",Invitrogen,Cat#:

(5) Preclinical evaluation of protein synthesis inhibitor omacetaxine in pediatric brainstem gliomasNeurooncol AdvMarch 29, 2024Yongjuan Chen, Aaminah Khan, Christopher Katsinas, Filip Michniewicz, Jessie Goldberg, Laura Franshaw, Maria Tsoli, David S Ziegler(#5625), Caspase 3 (#9662), cleaved Caspase 3 (#9664), phospho-H2A.X (#9718), phospho-PDGFRα (Tyr754) (#2992), PDGFRα (#3164), phospho-PI3K p85 (Tyr458)/p55 (Tyr199) (#4228), PI3K p85 (#4257), phospho-Akt (Ser473)

(6) A functional circuit formed by the autonomic nerves and myofibroblasts controls mammalian alveolar formation for gas exchangeDevelopmental cellJuly 11, 2022Zhang K, Yao E, Wang SA, Chuang E, Wong J, Minichiello L, Schroeder A, Eckalbar W, Wolters PJ, Chuang PT.RRID:AB_2162351 Rabbit monoclonal anti-Phospho-PDGF Receptor α (Tyr754) (23B2),Cell Signaling Technology,Cat# 2992; RRID:AB_390728 Goat polyclonal anti-PDGF R beta,R&D Systems,Cat# AF1042; RRID:AB_2162633 Rat monoclonal

(7) Acquisition of cellular properties during alveolar formation requires differential activity and distribution of mitochondriaeLifeApril 6, 2022Zhang K, Yao E, Chen B, Chuang E, Wong J, Seed RI, Nishimura SL, Wolters PJ, Chuang PT.Cell Signaling Technology, Cat# 3164), rabbit anti-phospho-PDGFRA (Tyr754) (1:100, Cell Signaling Technology, Cat# 2992), mouse anti-S6 ribosomal protein (1:100, Cell Signaling Technology, Cat# 2317), and rabbit anti-phospho-S6 ribosomal protein (Ser235/236

(8) Membrane extraction with styrene-maleic acid copolymer results in insulin receptor autophosphorylation in the absence of ligandScientific ReportsMarch 3, 2022Kerrie A. Morrison, Laura Wood, Karen J. Edler, James Doutch, Gareth J. Price, Francoise Koumanov, Paul Whitley(19H7) (1:500); Anti Phospho-Akt (Ser473) (193H12) (#4058) (1:1000); Anti phospho-PDGFR-α (Tyr754) (#2992) (1:1000); Anti PDGFR-α (#3174) (1:1000) were supplied by Cell Signalling Technology®. Pan 14-3-3 (K-19)

(9) In Silico Screening and Validation of PDGFRA Inhibitors Enhancing Radioiodine Sensitivity in Thyroid CancerFrontiers in pharmacologyJanuary 1, 2022Yu X, Zhu X, Zhang L, Qin JJ, Feng C, Li Q.for the western blot were as follows: monoclonal antibodies against phospho-PDGFRA (Tyr754, Cat. No. 2992), Na+/K+ ATPase (Cat. No. 3010), and GAPDH (Cat. No. 5174) were purchased from Cell Signaling Technology

(10) PDGFR-β signaling mediates HMGB1 release in mechanically stressed vascular smooth muscle cellsPloS oneJanuary 1, 2022Kim JO, Baek SE, Jeon EY, Choi JM, Jang EJ, Kim CD.purchased from Proteintech (Chicago, IL, USA). PDGFR-α (3164S), PDGFR-β (3169S) and phospho-specific (2992S, 3166S) antibodies were obtained from Cell Signaling Technology (Beverly, MA, USA). β-Actin (sc-47778)

(11) Cabozantinib Is Effective in Melanoma Brain Metastasis Cell Lines and Affects Key Signaling PathwaysInternational journal of molecular sciencesNovember 14, 2021Mannsåker TA, Hoang T, Aasen SN, Bjørnstad OV, Parajuli H, Sundstrøm T, Thorsen FA.the following antibodies: phospho-PDGFR-α (Cell Signaling Technology, Inc., Danvers, MA, USA, cat. #2992); phospho-MERTK (Abcam, Cambridge, UK, cat. #14921); phospho-IGF1 (Abcam, cat. #39398); phospho-DDR1

(12) Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drugCell ReportsNovember 2, 2021Junfeng Bi et al.,Cell Signaling,Cat#3174; RRID:AB_2162345 "Rabbit Anti-pPDGFRA-Tyr754, Clone 23B2 (WB 1:1000)",Cell Signaling,Cat#2992; RRID:AB_390728 "Rabbit Anti-FGFR1, Clone D8E4 (WB 1:1000)",Cell Signaling,Cat#9740; RRID:AB_11178519 "Mouse

(13) Prenatal overexpression of platelet-derived growth factor receptor A results in central nervous system hypomyelinationBrain and behaviorOctober 1, 2021Cardona HJ, Somasundaram A, Crabtree DM, Gadd SL, Becher OJ.3164S), 1:1000; myelin basic protein (MBP, CST, 78896), 1:1500; phospho‐Tyr762 PDGFRA (pPDGFRA, CST, 2992), 1:1000; ERK1/2 (CST, 9107), 1:1000; phospho‐Thr202/Tyr204 ERK1/2 (pERK1/2, CST, 9101), 1:1000; Akt

(14) Comparative Evaluation of qnrA, qnrB, and qnrS Genes in Enterobacteriaceae Ciprofloxacin-Resistant Cases, in Swine Units and a Hospital from Western RomaniaAntibiotics (Basel)October 14, 2020Alexandru O. Doma, Roxana Popescu, Mihai MituleÈ›u, Delia Muntean, JÃ¡nos DÃ©gi, Marius V. Boldea, Isidora Radulov, Eugenia Dumitrescu, Florin Muselin, Nikola PuvaÄa, et al.Methylase RmtB-Producing Escherichia coli Isolates from Pigs. Antimicrob. Agents Chemother. 2008, 52, 2992–2993. [CrossRef] Poirel, L.; Nguyen, T.V.; Weintraub, A.; Leviandier, C.; Nordmann, P. Plasmid-mediated

(15) GZD824 as a FLT3, FGFR1 and PDGFRα Inhibitor Against Leukemia In Vitro and In VivoTranslational oncologyApril 1, 2020Wang Y, Zhang L, Tang X, Luo J, Tu Z, Jiang K, Ren X, Xu F, Chan S, Li Y, et al.Cyclin E1 (20808S), Cyclin D2 (2924), CDK2 (2546S), CDK4 (12790S), PDGFRα (3174), phosphor-PDGFRα (2992 T), Stat3 (9132S), phosphor-Stat3 (9145S), GAPDH- (2118) and anti-rabbit (7074S) or anti-mouse IgG horseradish

(16) Activation of pH-Sensing Receptor OGR1 (GPR68) Induces ER Stress Via the IRE1α/JNK Pathway in an Intestinal Epithelial Cell ModelScientific reportsJanuary 29, 2020Maeyashiki C, Melhem H, Hering L, Baebler K, Cosin-Roger J, Schefer F, Weder B, Hausmann M, Scharl M, Rogler G, et al.After blocking with 3% bovine serum albumin (BSA), cells were incubated with LC3 antibody (Cat No. 2992, Cell Signalling Technology) at 1:200 dilution overnight at 4 °C. Cells were then incubated with an

(17) WEE1 kinase inhibitor AZD1775 induces CDK1 kinase-dependent origin firing in unperturbed G1- and S-phase cellsProceedings of the National Academy of SciencesNovember 26, 2019Tatiana N. Moiseeva, Chenao Qian, Norie Sugitani, Hatice U. Osmanbeyoglu, Christopher J. BakkenistMK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents. Mol. Cancer Ther. 8, 2992–3000 (2009). Moiseeva et al. BRIEF REPORT Materials and Methods Antibodies. Antibodies included MCM4

(18) An influenza virus-triggered SUMO switch orchestrates co-opted endogenous retroviruses to stimulate host antiviral immunityProceedings of the National Academy of Sciences of the United States of AmericaAugust 27, 2019Schmidt N, Domingues P, Golebiowski F, Patzina C, Tatham MH, Hay RT, Hale BG.Mount Sinai, New York, NY), PKR (abcam; ab32052), MDA5 (Cell Signaling; 5321), MAVS (Cell Signaling; 2992), STING (Cell Signaling; 13647), FLAG M2 (Sigma; F1804), and ubiquitin FK2 (Millipore; 04-263). SUMO

(19) Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid TumorsCell reportsAugust 27, 2019Oberlick EM, Rees MG, Seashore-Ludlow B, Vazquez F, Nelson GM, Dharia NV, Weir BA, Tsherniak A, Ghandi M, Krill-Burger JM, et al.AB_2756824 SMARCB1/SNF5,Bethyl,Cat#A301-087; RRID: AB_2779664 p-PDGFRα (Tyr754) (23B2),Cell Signaling,Cat#2992 ; RRID: AB_390728 p-PDGFRα (Tyr762),Cell Signaling,Cat#12022; RRID: AB_2636868 PDGFRα,Cell Signaling,Cat#3164;

(20) The Prognostic and Therapeutic Potential of LRIG3 and Soluble LRIG3 in GlioblastomaFrontiers in oncologyJanuary 1, 2019Cheng F, Zhang P, Xiao Q, Li Y, Dong M, Wang H, Kuang D, He Y, Duan Q, Mao F, et al.(Cell Signaling Technology, Cat# 3174S), rabbit anti-phospho-PDGFRα (Cell Signaling Technology, Cat# 2992), rabbit anti-MET (Cell Signaling Technology, Cat# 8198), rabbit anti-phospho-MET (Cell Signaling Technology,

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Phospho-PDGF Receptor alpha (Tyr754) (23B2) Rabbit mAb

Phospho-PDGF Receptor alpha (Tyr754) (23B2) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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Phospho-PDGF Receptor alpha (Tyr754) (23B2) Rabbit mAb from Cell Signaling Technology

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