The NF Kappa B-p105/p50 Monoclonal Antibody from Bioassay Technology Laboratory is a Mouse Monoclonal antibody. This antibody recognizes Human, Mouse, and Rat antigen. The NF Kappa B-p105/p50 Monoclonal Antibody has been shown to work in the following applications: EIA, Immunoassay, ELISA, Flow Cytometry, Immunohistochemistry, and Western Blot.
Description
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isof