The ASAP1 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to ASAP1. This antibody recognizes Human, Mouse, and Rat antigen. The ASAP1 Antibody has been shown to work in the following applications: ELISA, and Western Blot.
Description
Function: Possesses phosphatidylinositol 4, 5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types (By similarity). Plays a role in ciliogenesis.
Subunit Structure: Homodimer. Interacts with SRC and CRK. Interacts with RAB11FIP3. Interacts with PTK2B/PYK2 (By similarity). Interacts with CTTN. Interacts (via SH3 domain) with APC.
Post-translational Modifications: Phosphorylated on tyrosine residues by SRC.
Similarity: The PH domain most probably contributes to the phosphoinositide-dependent regulation of ADP ribosylation factors