The GABAA R alpha1 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to GABRA1. This antibody recognizes Human, Mouse, and Rat antigen. The GABAA R alpha1 Antibody has been shown to work in the following applications: ELISA, Immunohistochemistry, and Western Blot.
Description
Function: Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity).
Subunit Structure: Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains. Interacts with UBQLN1. Interacts with TRAK1. Interacts with KIF21B.
Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily