Rabbit Anti-pS2/pNR-2/TFF1 Antibody MBS4380703 from MyBioSource.com

Product Specs
ItemRabbit Anti-pS2/pNR-2/TFF1 Antibody
CompanyMyBioSource.com
Price $190.00Supplier Page View Company Product Page
Catalog NumberMBS4380703
Quantity0.02 mg (With BSA & Azide at 0.2mg/ml)
ApplicationsImmunohistology (Formalin-Fixed)
Conjugate/TagUnconjugated
Format200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml
PurityPurified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
ReactivityHuman, Cynomolgus Monkey. Others not known
TargetpS2/pNR-2/TFF1
IsotypeIgG
Molecular Weight6.5kDa
CloneTFF1/2969R
HostRabbit
ImmunogenIt recognizes a polypeptide of 6.5kDa, identified as pS2 estrogen-regulated protein. Its epitope is localized between aa57-84 of human pS2 protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. pS2 is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of response to endocrine therapy
NCBI Full Gene Nametrefoil factor 1
NCBI Gene AliasesHP1.A, pNR-2, BCEI, HPS2, pS2, D21S21
ClonalityMonoclonal