Rabbit Anti-TRAcP Antibody MBS4380160 from MyBioSource.com

Product Specs
ItemRabbit Anti-TRAcP Antibody
CompanyMyBioSource.com
Price $190.00Supplier Page View Company Product Page
Catalog NumberMBS4380160
ReactivityHu, Ms, Rt
ClonalityMonoclonal
NCBI Gene AliasesTRACP5b, TrATPase, TRACP5a, TRAP, HPAP
NCBI Full Gene Nameacid phosphatase 5, tartrate resistant
ApplicationsImmunohistochemistry-paraffin (IHC-p)
ImmunogenIt recognizes a protein of 35kDa, which is identified as tartrate-resistant acid phosphatase (TRAcP). It exists as two isoforms (5a and 5b). This MAb reacts with both the isoforms. Serum TRAcP 5a is secreted by macrophages and dendritic cells and increased in many patients of rheumatoid arthritis. Serum TRAcP 5b is produced from osteoclasts and elevated during bone resorption. TRAcP is an iron containing glycoprotein, which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. TRAcP is synthesized as a latent proenzyme and is activated by proteolytic cleavage and reduction. Normally, TRAcP is highly expressed by osteoclasts, activated macrophages, neurons and endometrium during pregnancy. Expression of TRAcP is increased in certain pathological conditions such as Leukemic Reticuloendotheliosis (Hairy Cell Leukemia), Gauchers Disease, HIV-induced Encephalopathy, Osteoclastoma and in osteoporosis and metabolic bone diseases. Anti-TRAcP antibody labels the cells of Hairy Cell Leukemia (HCL) with a high degree of sensitivity and specificity. Other cells stained with this antibody are tissue macrophages and osteoclasts
HostRabbit
CloneACP5/2336R
Molecular Weight35kDa
IsotypeIgG
TargetTRAcP (Tartrate-Resistant Acid Phosphatase)
Format200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml
Conjugate/TagUnconjugated
Quantity0.02 mg (With BSA & Azide at 0.2mg/ml)