MyBioSource.com's CEACAM3 Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, Immunohistochemistry, and Western Blot. The CEACAM3 Antibody was generated using CEACAM3 as the antigen and it reacts with Human, and Mouse.
Description
Description: Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis.
Subunit Structure: Interacts with S100A9/calprotectin. This interaction is calcium-dependent, but independent of CEACAM3 phosphorylation.
Post-translational Modifications: Tyrosine-phosphorylated in response to microbial binding. Tyr-230 and Tyr-241 are both required for phosphorylation to be detected.
Similarity: The cytosolic domain is involved in S100A9 interaction. Belongs to the immunoglobulin superfamily. CEA family