The LBR Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to Lamin B Receptor, and LBR. This antibody recognizes Human, and Mouse antigen. The LBR Antibody has been shown to work in the following applications: ELISA, Immunohistochemistry, and Western Blot.
Description
Description: The protein encoded by this gene belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.
Function: Anchors the lamina and the heterochromatin to the inner nuclear membrane.
Subunit Structure: Interacts directly with CBX5. Can interact with chromodomain proteins. Interacts directly with DNA. Interaction with DNA is sequence independent with higher affinity for supercoiled and relaxed circular DNA than linear DNA.
Post-translational Modifications: Phosphorylated by CDK1 in mitosis when the inner nuclear membrane breaks down into vesicles that dissociate from the lamina and the chromatin. It is phosphorylated by different protein kinases in interphase when the membrane is associated with these structures. Phosphorylation of LBR and HP1 proteins may be responsible for some of the alterations in chromatin organization and nuclear structure which occur at various times during the cell cycle. Phosphorylated by SRPK1. In late anaphase LBR is dephosphorylated, probably by PP1 and/or PP2A, allowing reassociation with chromatin.
Similarity: The Tudor domain may not recognize methylation marks, but rather bind unassembled free histone H3. Belongs to the ERG4/ERG24 family