The LAB Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to LAT2. This antibody recognizes Human, and Mouse antigen. The LAB Antibody has been shown to work in the following applications: ELISA, and Western Blot.
Description
Function: Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.
Subunit Structure: When phosphorylated, interacts with GRB2. May also interact with SOS1, GAB1 and CBL.
Post-translational Modifications: Phosphorylated on tyrosines following cross-linking of BCR in B-cells, FCGR1 in myeloid cells, or FCER1 in mast cells; which induces the recruitment of GRB2. May be polyubiquitinated