The VCAM1 Antibody from MyBioSource.com is a Mouse Monoclonal antibody to VCAM1. This antibody recognizes Human antigen. The VCAM1 Antibody has been shown to work in the following applications: ELISA, Immunohistochemistry, and Western Blot.
Description
Description: This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.
Function: Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
Subunit Structure: Binds to ECMV-D capsid proteins and acts as a receptor for this virus.
Post-translational Modifications: Sialoglycoprotein.
Similarity: Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion