The GAS2 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to GAS2. This antibody recognizes Human, Mouse, and Rat antigen. The GAS2 Antibody has been shown to work in the following applications: ELISA, Immunohistochemistry, and Western Blot.
Description
Description: The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2009]
Function: May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process (By similarity).
Post-translational Modifications: Cleaved, during apoptosis, on a specific aspartic residue by caspases. Phosphorylated on serine residues during the G0-G1 transition phase.
Similarity: Belongs to the GAS2 family