The SNIP Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to SRCIN1. This antibody recognizes Human, Mouse, and Rat antigen. The SNIP Antibody has been shown to work in the following applications: ELISA, Immunocytochemistry, Immunofluorescence, and Western Blot.
Description
Function: Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance.
Subunit Structure: Interacts with the N-terminal coiled-coil region of SNAP25 (By similarity). Interacts with BCAR1/p130Cas and SRC through its C-terminal domain. Interacts with CSK, CTTN, SORBS3/vinexin, SYP and MAPRE3/EB3.
Post-translational Modifications: Tyrosine-phosphorylated in response to EGF and to cell adhesion to integrin ligands.
Similarity: Belongs to the SRCIN1 family