The PLXNA2 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to Plxna2. This antibody recognizes Human, Mouse, and Rat antigen. The PLXNA2 Antibody has been shown to work in the following applications: ELISA, Immunohistochemistry, and Western Blot.
Description
Function: Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).
Subunit Structure: Homodimer. The PLXNA2 homodimer interacts with a SEMA6A homodimer, giving rise to a heterotetramer. Interacts directly with NRP1 and NRP2 (By similarity). Interacts with RND1.
Similarity: Belongs to the plexin family