MyBioSource.com's ASAP2 Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, and Western Blot. The ASAP2 Antibody was generated using ASAP2 as the antigen and it reacts with Human, and Mouse.
Description
Function: Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration.
Subunit Structure: Binds PXN, ARF1, ARF5, ARF6, PTK2B and SRC.
Post-translational Modifications: Phosphorylated on tyrosine residues by SRC and PTK2B.
Similarity: The conserved Arg-464 in the Arf-GAP domain probably becomes part of the active site of bound small GTPases and is necessary for GTP hydrolysis