The SLU7 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to SLU7. This antibody recognizes Human, Mouse, and Rat antigen. The SLU7 Antibody has been shown to work in the following applications: ELISA, Immunocytochemistry, Immunofluorescence, and Western Blot.
Description
Function: Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation.
Subunit Structure: Component of late spliceosomal complexes. Associates with the spliceosome prior to recognition of the 3'-splice site for step II, probably during catalysis of step I.
Similarity: The CCHC-type zinc finger is required to retain the protein within the nucleus and prevent its shuttle back to the cytoplasm via the CRM1 pathway. Belongs to the SLU7 family