MyBioSource.com's IL7 Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, Immunohistochemistry, and Western Blot.
Description
Description: IL-7 plays a key role in lymphopoiesis and lymphoid homeostasis (1). Stromal and epithelial cells within the bone marrow and thymus produce IL-7 (1). The primary targets of IL-7 are T cells, B cells, and dendritic cells (1). IL-7 is crucial for T cell development, the importance of which is underscored by the lack of T cells in both mice and humans that are deficient in IL-7/IL-7R signaling (1, 2). While IL-7 appears to be required for B cell development in mice, the role of IL-7 in human B cell development is unclear (1, 3). In addition to its effects on T cell lymphopoiesis, IL-7 promotes the maintenance and survival of na?ve and memory alphabeta T cells, as well as gammadelta T cells (1). The IL-7 receptor is a heterodimer of the common gamma chain, gammac, and the IL-7-specific IL-7Ralpha (1). IL-7 activates PI3K/Akt, Jak1/2, and Stat1, 3, and 5 (1).
Function: Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.
Similarity: Belongs to the IL-7/IL-9 family