Rabbit Anti-E-Cadherin/CD324 Antibody MBS4380383 from MyBioSource.com

Product Specs
ItemRabbit Anti-E-Cadherin/CD324 Antibody
CompanyMyBioSource.com
Price $190.00Supplier Page View Company Product Page
Catalog NumberMBS4380383
Quantity0.02 mg (With BSA & Azide at 0.2mg/ml)
ApplicationsFlow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunohistochemistry (IHC) Formalin
Conjugate/TagUnconjugated
Format200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml
ReactivityHuman
TargetE-Cadherin (CDH1)/CD324
IsotypeIgG
Molecular Weight120-80kDa (Mature); 135kDa (Precursor)
CloneCDH1/2208R
HostRabbit
ImmunogenRecognizes a protein of 120-80kDa, identified as E-cadherin. Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins, E-, N- andP-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as ?-catenin, to regulate cadherin function.E-cadherin plays an important role in epithelial cell adhesion. A decreased expression of E-cadherin is associated with metastatic potential and poor prognosis in breast cancer, prostate and esophageal cancer. In combination with p120 Catenin, it is useful for the differentiation between ductal (E-cadherin +) and lobular (E-cadherin -) breast carcinomas. It may also help in diagnosis of mesothelioma
NCBI Full Gene Namecadherin 1
NCBI Gene AliasesBCDS1, Arc-1, CDHE, ECAD, LCAM, UVO, CD324
ClonalityMonoclonal