Rac1/Cdc42 Antibody 4651S from Cell Signaling Technology

Product Specs
ItemRac1/Cdc42 Antibody
CompanyCell Signaling Technology
Price $306.00 Inquire
Catalog Number4651S
Quantity100 µl
ApplicationsW
ReactivityH, M, R, Mk
HostRabbit
TargetRac1;Cdc42
NCBI Full Gene NameRac family small GTPase 1, cell division cycle 42
NCBI Gene Aliasesp21-Rac1, MIG5, CDC42Hs, Rac-1, G25K, MRD48, TKS, TC-25
ClonalityPolyclonal
Research AreaCytoskeletal Signaling
Molecular Weight21

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Website: http://www.cellsignal.com/

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(1) Redox regulation of cell migration via Nischarin S-glutathionylationFree Radical Biology and MedicineFebruary 1, 2026Madhu C. Shivamadhu, Dhanushika S.K. Kukulage, Rayavarapu Padmavathi, Daniel Oppong, Faezeh Mashhadi Ramezani, Denaye N. Eldershaw, Brett M. Collins, Young-Hoon Ahnincubated with primary antibody solutions, such as PAK1 (1:1000), Rac1/Cdc42 (1:1000; Cell Signaling, Cat# 4651S), Igα−5 (1:1000; Cell Signaling, Cat# 4705S), or FLAG antibody (1:1000; Milipore-Sigma, Cat# F3165),

(2) A novel tRF-Gly is associated with obesity development through post-transcriptional regulation of lipid metabolismCellular & Molecular Biology LettersDecember 12, 2025Yuhang Lei, Mailin Gan, Kai Wang, Tianci Liao, Yiting Yang, Xue Zhao, Xin Zhang, Dujun Chen, Xinyi Wang, Jianfeng Ma, et al.14C10, 1:1000), anti-α-tubulin (no. 11H10, 1:1000), anti-β-tubulin (no. 2146, 1:1000), anti-RAC1 (no. 4651, 1:1000) and Argonaute 3 (no. 5054, 1:1000) were obtained from Cell Signaling Technology (Boston, USA).

(3) Laetiporus sulphureus Mycelial Extract Promotes Melanogenesis via p38 MAPK-Mediated Activation of β-Catenin/MITF and Rho Family Proteins in B16F10 CellsJ Microbiol BiotechnolDecember 9, 2025So Jung Park, Hyeok Jin Choi, Jeong Won Choi, Gyeong Eun Im, Youngki Park, Kyoung Tae Lee, Jin Boo Jeongdivision cycle 42 (Cdc42, cat. no. 2462), Ras-related C3 botulinum toxin substrate 1 (Rac 1, cat. no. 4651), Ras homolog family member A (RhoA, cat. no. 2117), and β-actin (5125) (all from Cell Signaling Technology,

(4) Radiation-induced eCIRP causes macrophage phagocytic dysfunction via mitochondrial impairment and ferroptosisFrontiers in ImmunologyNovember 20, 2025Mian Zhou, Gaifeng Ma, Jingsong Li, Satoshi Yamaga, Max Brenner, Monowar Aziz, Ping Wangincubated overnight at 4°C with primary antibodies against GPX4 (67763-1-Ig, Proteintech, 1:300), Rac1 (4651S, Cell Signaling Technology, 1:300), and β-actin (A5441, MilliporeSigma, 1:30,000). After washing, membranes

(5) Mevalonate metabolites boost aged oocyte quality through prenylation of small GTPasesNature AgingAugust 26, 2025Chuanming Liu, Huidan Zhang, Jialian Mao, Sainan Zhang, Xiao Tian, Yibing Zhu, Changjiang Wang, Junshun Fang, Huijie Pan, Nannan Kang, et al.monoclonal anti-CDC42 (Abcam, ab187643; 1:1,000), rabbit monoclonal anti-RAC1 (Cell Signaling Technology, 4651S; 1:1,000), rabbit monoclonal anti-Arp2 (Abcam, ab128934; 1:1,000), rabbit monoclonal anti-Arp3 (Abcam,

(6) MicroRNA-129-5p-mediated translational repression of microglial ROCK1 leads to enhanced phagocytosisJournal of Biological ChemistryJuly 1, 2025Rajib Kumar Dey, Ranjana Kumari, Roni Patra, Dharmendra Kumar Soni, Roopa Biswas, Satyakam Patnaik, Debabrata Ghosh(IPVH00010) and chemiluminescence substrates (WBKL50500) were obtained from Merck-Millipore. The Rac1(4651T, CST, dilution 1:2500) PSD95 (3450S, CST, dilution 1:1000), Iba1 (MABN92, Millipore, dilution 1:1000),

(7) LncRNA NEAT1 regulation of the miR-101-3p/RAC1 axis affects cervical cancer aerobic glycolysis and progressionSci RepMay 20, 2025Lingling Cao, Wumidan Abudureheman, Guqun Shen, Yunshan Ouyang, Wang Yang, Qian Zhao, Tianze Lu, Chen Lintechnology,A21052 PFKP,1:1000,Cell signaling technology,A20983 RAC1,1:1000,Cell signaling technology,4651T GLUT1,1: 5000,Proteintech,21829-1-AP LDHA,1: 4000,Proteintech,19987-1-AP β-actin,1: 5000,Affinity,AF7018 Goat

(8) Prognostic value of immunohistochemical staining for H3K27me3 and EZH2 in astrocytoma, IDH-mutantJournal of Neuro-OncologyDecember 5, 2024Shumpei Onishi, Fumiyuki Yamasaki, Vishwa Jeet Amatya, Ushio Yonezawa, Akira Taguchi, Iori Ozono, Novita Ikbar Khairunnisa, Yukari Go, Yukio Takeshima, Nobutaka Horie(1:200, #9733, Cell Signaling Technology, Danvers, MA, USA), rabbit monoclonal anti-EZH2 (1:100, 790–4651, Cell Signaling Technology), anti-H3K27M (#ABE419, Millipore, Billerica, MA, USA; 1 µg/mL), rabbit monoclonal

(9) The Protective Role of Intermedin in Contrast-Induced Acute Kidney Injury: Enhancing Peritubular Capillary Endothelial Cell Adhesion and Integrity Through the cAMP/Rac1 PathwayInternational journal of molecular sciencesOctober 16, 2024Gao T, Gu R, Wang H, Li L, Zhang B, Hu J, Tian Q, Chang R, Zhang R, Zheng G, et al.USA); CD34 (BM4082, Boster, Wuhan, China); ICAM1 VEGFR2 (A00901-3, Boster, Wuhan, China); Rac1/Cdc42 (4651, Cell Signaling Technology, Danvers, MA, USA); Phospho-Rac1/cdc42 (#2461, Cell Signaling Technology,

(10) Homeostatic Shrinkage of Dendritic Spines Requires Melatonin Type 3 Receptor Activation During SleepAdvanced science (Weinheim, Baden-Wurttemberg, Germany)October 1, 2024Li S, Li X, Lu M, Chen Q, Yao D, Yu X, Li Z, Ge WP, Wang N, Jin J, et al.anti‐Phospho‐PSD95 (Tyr236/Tyr240) (CST, 3919S), anti‐Phospho‐Synapsin‐1(Ser605) (CST, 88246S), anti‐Rac1/Cdc42 (CST, 4651S), anti‐Phospho‐PKA Substrate (CST, 9624S), anti‐Phospho‐PKC Substrate Motif (CST, 6967S), anti‐GAPDH

(11) Dissemination of pathogenic bacteria is reinforced by a MARTX toxin effector duetNature communicationsJuly 23, 2024Choi S, Lee Y, Park S, Jang SY, Park J, Oh DW, Kim SM, Kim TH, Lee GS, Cho C, et al.PA5-37718). The following antibodies were from Cell Signaling Technology: anti-Rac1/Cdc42 (1:1000, #4651), anti-p-ERK1/2 T202/Y204 (1:1000, #9101), anti-ERK1/2 (1:1000, #4695), anti-p-SAPK/JNK T183/Y185 (1:1000,

(12) A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screensNature structural & molecular biologyMarch 1, 2024Mattson NM, Chan AKN, Miyashita K, Mukhaleva E, Chang WH, Yang L, Ma N, Wang Y, Pokharel SP, Li M, et al.ITGAV (4711, Cell Signaling Technology, 1:1000), ITGB5 (3629, Cell Signaling Technology; 1:1000), RAC1 (4651, Cell Signaling Technology; 1:1000) and β-actin (ab8226, Abcam; 1:5000) at 4 °C overnight. After the

(13) HOXD10 regulates intestinal permeability and inhibits inflammation of dextran sulfate sodium-induced ulcerative colitis through the inactivation of the Rho/ROCK/MMPs axisOpen medicine (Warsaw, Poland)January 1, 2024Xu J, Lin N.Abclonal, China), RhoA rabbit mAb (1:1,000, A19106; Abclonal, China), Rac1/Cdc42 antibody (1:1,000, 4651; Cell Signaling Technology, USA), ROCK1 rabbit mAb (1:1,000, A11158; Abclonal, China), ROCK2 rabbit mAb

(14) Polo-like kinase-1 mediates hepatitis C virus-induced cell migration, a drug target for liver cancerLife science allianceNovember 1, 2023El-Khobar KE, Tay E, Diefenbach E, Gloss BS, George J, Douglas MW.Cell Signaling Technology (#3128, #4738, #2144, #4970, #3195, #9812, #4848, #8456, #9062, #4513, #2461, #4651, #5741, and #3659). PLK1 primary antibody used for immunofluorescence was purchased from Thermo Fisher Scientific

(15) Tiam1 coordinates synaptic structural and functional plasticity underpinning the pathophysiology of neuropathic painNeuronJuly 5, 2023Li L, Ru Q, Lu Y, Fang X, Chen G, Saifullah AB, Yao C, Tolias KF.anti-Tiam1,Santa Cruz,SC-872 Sheep anti-Tiam1,R&D Systems,AF5038 Rabbit anti-Rac1,Cell Signaling,4651 Mouse anti-Actin,Millipore,MAB1501 Rabbit anti-GluN1,Sigma,G8913 Rabbit anti-GluN1,Abcam,AB52177 Rabbit

(16) Esculin alleviates LPS-induced acute lung injury via inhibiting neutrophil recruitment and migrationInternational ImmunopharmacologyJune 1, 2023Jiangwei Ni, Ge Li, Ningfeng Dai, Zijiao Quan, Haibin Tong, Yu Liu(#3318), anti-phospho-cofilin (#3311), anti-p65 (#8242), anti-p-p65 (#3033), anti-GST (#2624), anti-Rac1 (#4651), anti-ICAM-1 (#4915), anti-β2 integrin (#73663) and anti-β-actin (#4970) antibodies were purchased

(17) Integrative Multi-OMICs Identifies Therapeutic Response Biomarkers and Confirms Fidelity of Clinically Annotated, Serially Passaged Patient-Derived Xenografts Established from Primary and Metastatic Pediatric and AYA Solid TumorsCancersDecember 30, 2022Pandya PH, Jannu AJ, Bijangi-Vishehsaraei K, Dobrota E, Bailey BJ, Barghi F, Shannon HE, Riyahi N, Damayanti NP, Young C, et al.anti-PTEN (54 kDa, cat# 9559, Cell Signaling Technology, Boston, MA, USA); rabbit anti-RAC1 (21 kDa, cat# 4651, Cell Signaling Technology, Boston, MA, USA); rabbit anti-HSP90Aβ1 (96 kDa, cat# NBP2-68937, Novus Biologicals,

(18) Targeting TLR2/Rac1/cdc42/JNK Pathway to Reveal That Ruxolitinib Promotes ThrombocytopoiesisInternational journal of molecular sciencesDecember 17, 2022Yang S, Tang X, Wang L, Ni C, Wu Y, Zhou L, Zeng Y, Zhao C, Wu A, Wang Q, et al.22008–1-AP), RUNX1 (Proteintech, USA, 25315-1-AP), TLR2 (Proteintech, USA, 17236-1-AP), Rac1/cdc42 (CST, USA, 4651S), JNK (Abmart, China, T55490), p-JNK (Abmart, China, T55541), NF-E2 (Proteintech, USA, 11089-1-AP),

(19) Increased migration and motility in XIAP-null cells mediated by the C-RAF protein kinaseScientific ReportsDecember 1, 2022Lauren G. Russell, Lydia A. K. Davis, Jill E. Hunter, Neil D. Perkins, Niall S. Kenneth(ab28151, Abcam), cIAP1 (1E1-1–10, Enzo Life Sciences), C-RAF (A301-519A, Bethyl Laboratories) Rac1/Cdc42 (#4651, Cell Signalling Technologies) and Actin (Ac74, Sigma). Caspase activity assay Cells were seeded into

(20) SMAD2/3 mediate oncogenic effects of TGF-β in the absence of SMAD4Communications biologyOctober 7, 2022Bertrand-Chapel A, Caligaris C, Fenouil T, Savary C, Aires S, Martel S, Huchedé P, Chassot C, Chauvet V, Cardot-Ruffino V, et al.phospho-SMAD2 (Ser465/467) (#3108), phospho-SMAD3 (Ser423/425) (#9520), SMAD2/3 (#8685), SMAD4 (#46535), RAC1 (#4651), βIG-H3 (#5601) and Leupaxin (#59309) were purchased from Cell Signaling. The anti-GAPDH antibody (#8245),

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Rac1/Cdc42 Antibody

Rac1/Cdc42 Antibody from Cell Signaling Technology

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Cell Signaling Technology

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Rac1/Cdc42 Antibody from Cell Signaling Technology

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