MyBioSource.com's Anti-GR Rabbit Monoclonal Antibody is a Rabbit monoclonal antibody. The Anti-GR Rabbit Monoclonal Antibody was generated using NR3C1 as the antigen. It reacts with Human, Mouse, and Rat. This antibody has been shown to work in applications such as: Flow Cytometry, and Western Blot.
Description
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression